Indications & Uses
Xderm is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage for Cream and Ointment: For adults, the elderly, and children over 1 year, apply a thin layer of Clobetasol Propionate Cream or Ointment to the affected skin areas twice daily, rubbing it in gently and completely. Repeated short courses of Clobetasol Propionate may be used to control flare-ups. In more resistant lesions, especially where thickened skin is present, the effect of Clobetasol can be enhanced, if necessary, by covering the treated area with polythene film. Overnight covering alone is usually enough to bring about a satisfactory response. Clobetasol Propionate is a super-high potency topical corticosteroid, so treatment should be limited to 2 consecutive weeks, and the maximum weekly dose should not exceed 50 gm per week. For children, courses should be limited if possible to five days and reviewed weekly. Spray: Apply the required amount of spray once or twice daily to the affected areas of the scalp and rub in gently. The total dose applied should not exceed 50 ml per week. If needed, Clobetasol Propionate scalp solution may be massaged into the scalp using the fingertips. Treatment should be stopped if no response is seen after one week, or as soon as the lesion heals. It is advisable to use Clobetasol Propionate scalp solution only for brief periods. Shampoo: This should be applied to a dry, not wet, scalp once a day, to the affected areas only. It should be massaged gently into the lesions and left in place for 15 minutes before lathering and rinsing. Treatment should be limited to 4 consecutive weeks, and the total dosage of shampoo should not exceed 50 g per week. This preparation is not recommended for those under 18 years of age. Scalp Solution: Apply the required amount of Clobetasol Scalp Solution spray once or twice daily to the affected areas of the scalp and rub in gently. The total dose applied should not exceed 50 ml per week. If needed, Clobetasol Scalp Solution may be massaged into the scalp using the fingertips. Treatment should be stopped if no response is seen after one week, or as soon as the lesion heals. It is advisable to use Clobetasol Scalp Solution only for brief periods.
Side Effects
Prolonged use of large amounts of any topical corticosteroid, or treatment over extensive areas of skin, can result in enough of the drug being absorbed into the body to produce features of hypercorticism, the same is true here. Prolonged, intensive treatment with a highly active corticosteroid preparation may cause local atrophic changes in the skin, such as thinning, stretch marks and widening of the small surface blood vessels; this is more likely when occlusive dressings are used or when skin folds are involved. In rare cases, treating psoriasis with corticosteroids, or withdrawing such treatment, is thought to have triggered the pustular form of the disease. Changes in skin pigmentation and excessive hair growth have also been reported with topical steroids. Dersole is usually well tolerated, but treatment should be stopped at once if signs of hypersensitivity appear, since a flare-up of symptoms may follow.
Cautions & Contraindications
Warnings & Precautions
Long-term, continuous use of this medicine on the skin should be avoided wherever possible, especially in infants and children, since it can suppress adrenal gland function even without the area being covered or bandaged. When used in children or on the face, treatment should ideally be limited to five days at a time, and the treated area should not be covered or bandaged. The face tends to develop thinning and other skin changes more readily than other body areas after prolonged use of strong topical corticosteroids. This is important to keep in mind when treating conditions such as psoriasis, discoid lupus erythematosus, and severe eczema. If applying near the eyelids, care must be taken to keep the medicine out of the eyes, as this could lead to glaucoma or cataract. Topical corticosteroids can be risky in psoriasis for several reasons, including flare-ups after stopping treatment, the skin becoming less responsive over time, the risk of a serious generalised pustular form of psoriasis, and local or body-wide toxicity from the skin's protective barrier being weakened. Patients with psoriasis should therefore be monitored closely during treatment. If the skin area being treated becomes infected, an appropriate antimicrobial medicine should be used alongside the corticosteroid. If the infection spreads, the corticosteroid should be stopped and an antimicrobial medicine taken by mouth or injection should be started. Covering or bandaging the skin can create a warm, moist environment that encourages bacterial infection, so the skin should be cleaned each time before a fresh dressing is applied.
Contraindications
Rosacea, acne vulgaris, and perioral dermatitis. Primary skin infections caused by viruses (such as herpes simplex or chickenpox). Known hypersensitivity to any component of the preparation. Clobetasol Propionate skin preparations should not be used to treat skin lesions that are primarily infected with fungi (such as candidiasis or tinea) or bacteria (such as impetigo), or for itching around the anus or genitals. It should also not be used for skin conditions, including dermatitis and nappy (diaper) rash, in children under one year of age.