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Other brands with the same active ingredient
These brands contain the same active ingredient (Clarithromycin). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Remac Granules
Rx125 mg • Powder For Suspension
Indications & Uses
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: For an acute bacterial exacerbation of chronic bronchitis, the usual dose is 250 mg to 500 mg every 12 hours for 7 to 14 days. For acute maxillary sinusitis, 500 mg is given every 12 hours for 14 days. For community-acquired pneumonia, the dose is 250 mg every 12 hours for 7 to 14 days. For pharyngitis or tonsillitis, 250 mg is given every 12 hours for 10 days. For uncomplicated skin and skin structure infections, the dose is 250 mg every 12 hours for 7 to 14 days. For treatment and prophylaxis of disseminated Mycobacterium avium disease, 500 mg is given every 12 hours until the patient is considered at low risk of disseminated infection. Combination dosing regimens for H. pylori infection are as follows. In triple therapy with clarithromycin, lansoprazole and amoxicillin, the recommended adult dosage is 500 mg clarithromycin, 30 mg lansoprazole and 1 g amoxicillin, all given every 12 hours for 10 or 14 days. In triple therapy with clarithromycin, omeprazole and amoxicillin, the recommended adult dosage is 500 mg clarithromycin, 20 mg omeprazole and 1 g amoxicillin, all given every 12 hours for 10 or 14 days. In patients who have an ulcer present at the start of therapy, an additional 14 or 18 days of omeprazole 20 mg once daily is recommended for ulcer healing and symptom relief. In dual therapy with clarithromycin and omeprazole, the recommended adult dosage is 500 mg clarithromycin given every 8 hours and 40 mg omeprazole given once every morning for 14 days, with an additional 14 days of omeprazole 20 mg once daily recommended for ulcer healing and symptom relief. Children: The recommended daily dosage is 15 mg/kg/day divided every 12 hours for 10 days. For treatment and prophylaxis of mycobacterial infections in pediatric patients, the recommended dose is 7.5 mg/kg every 12 hours, up to 500 mg every 12 hours. Renal and hepatic impairment: Clarithromycin is excreted principally via the liver and kidney. It may be administered without dosage adjustment to patients with hepatic impairment and normal renal function. However, in the presence of severe renal impairment, with or without coexisting hepatic impairment, a decreased dose or prolonged dosing interval may be appropriate.
Side Effects
Binoclar is generally well tolerated. Side effects include nausea, vomiting, diarrhoea and abdominal pain. Stomatitis and glossitis have also been reported. Other side effects include headache and allergic reactions ranging from urticaria and mild skin reactions to anaphylaxis. Taste perversion may occur. There have been reports of transient central nervous system side effects including anxiety, dizziness, insomnia and hallucination.
Cautions & Contraindications
Warnings & Precautions
Binoclar should be stopped if severe acute hypersensitivity reactions occur. It should be avoided in patients with known QT prolongation, those taking drugs known to prolong the QT interval, ventricular arrhythmia, low blood potassium or magnesium levels, marked bradycardia, or those on Class IA or III antiarrhythmic medicines. Treatment should be stopped if signs and symptoms of hepatitis appear. In patients with coronary artery disease, there is an increased risk of death from any cause starting one year or more after treatment ends; this potential risk should be weighed against the benefits of treatment when prescribing Binoclar to these patients. If diarrhea develops, the patient should be assessed for Clostridium difficile associated diarrhea (CDAD). Worsening of myasthenia gravis has been reported in patients taking Binoclar.
Contraindications
Clarithromycin should not be used by anyone who is hypersensitive to it, to erythromycin, to other macrolide antibacterials, or to any other ingredient in this product. It should also be avoided by anyone who has previously developed cholestatic jaundice or liver dysfunction while taking clarithromycin.