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Aminophylline

Bronchodilator Prescription
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Indications

Heart Failure Asthma Chronic Obstructive Pulmonary Disease Bronchitis

Aminophylline is used to treat and prevent bronchospasm (tightening of the airways) associated with asthma, emphysema and chronic bronchitis. In adults, it is also used to treat cardiac asthma and left ventricular or congestive cardiac failure.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Aminophylline is made up of two components: theophylline, the active drug, and ethylenediamine, which has no drug effect of its own but helps theophylline dissolve more readily in water. It is the theophylline portion that relaxes the smooth muscle lining the airways. This bronchodilating effect is thought to arise from several combined actions: theophylline inhibits the phosphodiesterase enzyme, which raises intracellular cAMP levels, and it also blocks adenosine and prostaglandin receptors while influencing calcium movement within cells.

Pregnancy & Breastfeeding

Doctors typically weigh the use of aminophylline during pregnancy against the risks of leaving the underlying condition untreated.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Dosage. Oral, for chronic bronchospasm. Adults: as the hydrate, start with 225 to 450 mg twice daily, increased if necessary. Children over 3 years: as the modified-release hydrate, 12 mg/kg daily, increased to 24 mg/kg daily in 2 divided doses after 1 week. Intravenous, for acute severe bronchospasm. Adults: a loading dose of 5 mg/kg (based on ideal body weight) or 250 to 500 mg (25 mg/ml) given by slow injection or infusion over 20 to 30 minutes, followed by a maintenance infusion of 0.5 mg/kg per hour. The maximum rate is 25 mg per minute. Children: the loading dose is the same as the adult dose. Maintenance dose for children aged 6 months to 9 years is 1 mg/kg per hour, and for those aged 10 to 16 years it is 0.8 mg/kg per hour. Elderly patients: dose reduction may be necessary. Hepatic impairment: dose reduction may be necessary.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.