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Other brands with the same active ingredient
These brands contain the same active ingredient (Aminophylline). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
A-Phyline is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage. Oral, for chronic bronchospasm. Adults: as the hydrate, start with 225 to 450 mg twice daily, increased if necessary. Children over 3 years: as the modified-release hydrate, 12 mg/kg daily, increased to 24 mg/kg daily in 2 divided doses after 1 week. Intravenous, for acute severe bronchospasm. Adults: a loading dose of 5 mg/kg (based on ideal body weight) or 250 to 500 mg (25 mg/ml) given by slow injection or infusion over 20 to 30 minutes, followed by a maintenance infusion of 0.5 mg/kg per hour. The maximum rate is 25 mg per minute. Children: the loading dose is the same as the adult dose. Maintenance dose for children aged 6 months to 9 years is 1 mg/kg per hour, and for those aged 10 to 16 years it is 0.8 mg/kg per hour. Elderly patients: dose reduction may be necessary. Hepatic impairment: dose reduction may be necessary.
Side Effects
The most common side effects are stomach irritation, nausea, vomiting, diarrhoea, vomiting of blood (hematemesis), pain in the upper abdomen and tremor. These are usually early warning signs of toxicity. With high doses, however, ventricular arrhythmias or seizures may be the first signs to appear. Other possible effects include reactivation of a peptic ulcer, headache, irritability, restlessness, difficulty sleeping, twitching, convulsions and reflex hyperexcitability, palpitations, a rapid heartbeat (tachycardia), low blood pressure, circulatory failure, ventricular arrhythmias, flushing, protein in the urine (albuminuria), increased urination and blood in the urine (hematuria). Inappropriate ADH syndrome may also occur.
Cautions & Contraindications
Warnings & Precautions
Filin should be used with caution in patients with peptic ulcer disease, hyperthyroidism, high blood pressure, cardiac arrhythmias or other cardiovascular disease, or epilepsy, as these conditions may be made worse. Caution is also needed in patients with heart failure, liver dysfunction, or chronic alcoholism, in those with an acute febrile illness, and in neonates and the elderly. In all of these circumstances, theophylline clearance may be reduced, leading to higher serum theophylline concentrations and a longer serum half-life.
Contraindications
Aminophylline should not be given to anyone who is hypersensitive to xanthines or ethylenediamine. It should also not be given to patients with an active peptic ulcer, because it can increase the volume and acidity of stomach secretions.