Alendronic Acid + Vitamin D3
Indications
Alendronic Acid & Vitamin D3 is used for the treatment of osteoporosis in both postmenopausal women and men. By increasing bone mass and lowering the risk of fractures, including those of the hip and spine, it helps in the treatment of osteoporosis.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Alendronate sodium belongs to the bisphosphonate class and works by specifically inhibiting osteoclast-mediated bone resorption. To be effective, it should be taken at least 30 minutes before breakfast. After administration, it briefly distributes into soft tissues before being rapidly taken up by bone or excreted in the urine, and it is roughly 78% bound to plasma proteins. There is no evidence that it is metabolised in either animals or humans.
At the cellular level, Alendronate concentrates preferentially at sites of bone resorption, particularly beneath osteoclasts, where it suppresses their activity. As a result, bone formation comes to outpace bone resorption, producing a progressive increase in bone mass.
Vitamin D, for its part, is essential for normal bone formation. When both sunlight exposure and dietary intake fall short, Vitamin D insufficiency can develop, and this is linked to a negative calcium balance, raised parathyroid hormone levels, bone loss, and a greater risk of fracture.
Pregnancy & Breastfeeding
Pregnancy category C. In animal studies, very high doses of vitamin D caused birth defects, so Alendronic Acid & Vitamin D3 (Colecalciferol) should be used during pregnancy only if the expected benefit to the mother outweighs the possible risk to her and the unborn baby. Cholecalciferol and some of its active breakdown products pass into breast milk, and it is not known whether alendronate does as well. This combination should therefore be used with caution in breastfeeding mothers.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.