Alendronic Acid + Vitamin D3

ইঙ্গিত

Osteoporosis

Alendronic Acid & Vitamin D3 is used for the treatment of osteoporosis in both postmenopausal women and men. By increasing bone mass and lowering the risk of fractures, including those of the hip and spine, it helps in the treatment of osteoporosis.

⚠️ কোনো ওষুধ গ্রহণের আগে সর্বদা নিবন্ধিত চিকিৎসকের পরামর্শ নিন।

ফার্মাকোলজি

Alendronate sodium belongs to the bisphosphonate class and works by specifically inhibiting osteoclast-mediated bone resorption. To be effective, it should be taken at least 30 minutes before breakfast. After administration, it briefly distributes into soft tissues before being rapidly taken up by bone or excreted in the urine, and it is roughly 78% bound to plasma proteins. There is no evidence that it is metabolised in either animals or humans.

At the cellular level, Alendronate concentrates preferentially at sites of bone resorption, particularly beneath osteoclasts, where it suppresses their activity. As a result, bone formation comes to outpace bone resorption, producing a progressive increase in bone mass.

Vitamin D, for its part, is essential for normal bone formation. When both sunlight exposure and dietary intake fall short, Vitamin D insufficiency can develop, and this is linked to a negative calcium balance, raised parathyroid hormone levels, bone loss, and a greater risk of fracture.

Pregnancy & Breastfeeding

Pregnancy category C. In animal studies, very high doses of vitamin D caused birth defects, so Alendronic Acid & Vitamin D3 (Colecalciferol) should be used during pregnancy only if the expected benefit to the mother outweighs the possible risk to her and the unborn baby. Cholecalciferol and some of its active breakdown products pass into breast milk, and it is not known whether alendronate does as well. This combination should therefore be used with caution in breastfeeding mothers.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

ডোজ নির্দেশিকা

⚠️ শুধুমাত্র সরকারি উৎস থেকে নির্দেশিকা পরিসীমা। ব্যক্তিগতকৃত ডোজের জন্য আপনার ডাক্তারের পরামর্শ নিন।

Adults: Dosage for Treatment of Osteoporosis in Postmenopausal Women: The recommended dose is 70 mg alendronate combined with either 2800 IU or 5600 IU of vitamin D3, taken as one tablet once weekly. For most women with osteoporosis, the 70 mg alendronate and 5600 IU vitamin D3 combination is the appropriate choice. Dosage to Increase Bone Mass in Men with Osteoporosis: The recommended dose is 70 mg alendronate combined with either 2800 IU or 5600 IU of vitamin D3, taken as one tablet once weekly. For most men with osteoporosis, the 70 mg alendronate and 5600 IU vitamin D3 combination is the appropriate choice.

পার্শ্বপ্রতিক্রিয়া ও পারস্পরিক ক্রিয়া

পার্শ্বপ্রতিক্রিয়া

No side-effect data recorded yet.

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