Flecainide Acetate Clozapine
ModerateIf you take clozapine together with flecainide, the body breaks down both medicines through the same enzyme, cytochrome P450 2D6. That means the doses of one or both may need to be lowered. The same applies to phenothiazines, antidepressants, propafenone, encainide and quinidine, which either share this route or block the enzyme.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.