Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Parkinson's Disease Schizophrenia

Sensipin is used to treat schizophrenia in patients who have not responded well to, or cannot tolerate, standard antipsychotic medicines. It is also used for psychosis occurring in Parkinson's disease.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Clozapine is classified as an "atypical" antipsychotic because its profile of binding to dopamine receptors, and its effects on various dopamine-mediated behaviors, differ from those seen with other typical antipsychotic drugs. Clozapine does interfere with the binding of dopamine at the D1, D2, D3 and D5 receptors, and it has a high affinity for the D4 receptor. This evidence supports the view that Clozapine is preferentially more active at limbic than at striatal dopamine receptors, which may explain its relative freedom from extrapyramidal side effects. Clozapine also acts as an antagonist at adrenergic, cholinergic, histaminergic and serotonergic receptors.

Pregnancy & Breastfeeding

Clozapine hasn't been studied thoroughly in pregnant women, though animal studies haven't pointed to any significant risk to the developing baby. If a doctor judges it necessary, it can still be used during pregnancy. As for breastfeeding, animal research shows Clozapine passes into breast milk, so mothers taking this medicine should avoid nursing their infants.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Schizophrenia For adults over 16 years, the starting dose is 12.5 mg, taken once or twice on the first day. The elderly start at 12.5 mg once. On the second day, the dose goes to 25 to 50 mg (for the elderly, 25 to 37.5 mg). After that, the dose is raised gradually, provided it is well tolerated, in steps of 25 to 50 mg a day. In the elderly, the largest daily increase is 25 mg. This build-up takes 14 to 21 days, and the daily dose can reach up to 300 mg, split into divided doses with the larger share at night. Up to 200 mg a day may be taken as a single dose at bedtime. If needed, the dose can be increased further in steps of 50 to 100 mg, preferably once a week, though twice a week is also possible. The usual dose is 200 to 450 mg a day, and the maximum is 900 mg a day. Psychosis in Parkinson's disease For adults over 16 years, the dose is 12.5 mg at bedtime. It is then increased according to the response, in steps of 12.5 mg, up to twice a week. The usual dose range is 25 to 37.5 mg at bedtime, and the usual maximum is 50 mg a day. In exceptional cases, the dose may be raised further in steps of 12.5 mg a week, up to a maximum of 100 mg a day, taken in 1 or 2 divided doses.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.