In studies on healthy people, esomeprazole, the acid-reducing part of this combination, showed no important interaction with propranolol. Both medicines are broken down by the liver's cytochrome P450 system. Even so, esomeprazole did not noticeably change how propranolol works. These studies did not look at the other two medicines in the pack, amoxicillin and clarithromycin, so they say nothing about those.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.