Pharmacology
Esomeprazole lowers stomach acid by blocking the last step of acid production. It binds covalently to the sulfhydryl groups of cysteines on the (H+, K+)-ATPase enzyme, which sits at the secretory surface of the gastric parietal cells. This inhibits both basal and stimulated gastric acid secretion, whatever the stimulus. The binding is irreversible, and new enzyme has to be expressed before acid secretion can start again. So the antisecretory effect of esomeprazole lasts longer than 24 hours.
Amoxicillin is similar to penicillin in the way it kills bacteria. It acts on susceptible bacteria during the stage of active multiplication. It inhibits cell wall biosynthesis, and this leads to the death of the bacteria.
Clarithromycin works by inhibiting microsomal protein synthesis in susceptible organisms. It does this mainly by binding to the donor site on the 50S subunit of the bacterial ribosome, which prevents translocation to that site.
Pregnancy & Breastfeeding
Esomeprazole + Amoxicillin + Clarithromycin should be given to a pregnant woman only when its use is considered essential. For breastfeeding, nobody has established yet whether this combination is safe for the infant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.