Methylergonovine Maleate Nelfinavir
ModerateMethylergonovine and nelfinavir should not be taken together without care, because nelfinavir belongs to a group of HIV protease or reverse transcriptase inhibitors that strongly block the CYP 3A4 enzyme. This enzyme is what breaks methylergonovine down in the body, so when it is blocked, methylergonovine can build up to unsafe levels.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.