Treosulfan Midazolam
ModerateModelling based on the body's physiology (PBPK modelling) was run using midazolam, omeprazole and digoxin as sensitive markers for the enzymes CYP3A4 and CYP2C19 and for the transporter P-gp. The model predicted a weak interaction with Treosulfan for CYP3A4 and CYP2C19, with an AUC ratio of 1.25 or more but less than 2. For P-gp, the interaction was predicted to be negligible, with an AUC ratio below 1.25.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.