Pharmacology
Treosulfan is a prodrug of a bifunctional alkylating agent, and it is toxic to hematopoietic stem cells. It doesn't act in its original form. In the body it changes on its own, depending on pH, into a mono-epoxide intermediate and di-epoxybutan. These epoxides alkylate and cross-link nucleophilic centers of deoxyribonucleic acid (DNA) and of other biological molecules that take part in various physiological functions. They are considered responsible for the stem cell depleting, immune-suppressive and antineoplastic effects of treosulfan.
Pregnancy & Breastfeeding
No one has used treosulfan in pregnant women, so there is no experience to go on. Treosulfan must not be used during pregnancy. It isn't known whether the medicine passes into human breast milk, but many drugs do, so care is needed. Breastfeeding should be stopped during treatment with treosulfan.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.