Treosulfan Omeprazole
ModerateComputer modelling (PBPK) used omeprazole as a sensitive test drug for the CYP2C19 enzyme to predict how treosulfan might affect other medicines. It predicted a weak interaction for CYP2C19, with an AUC ratio of 1.25 or more but below 2. The same modelling predicted a weak interaction for CYP3A4 as well, using midazolam as the test drug for that enzyme, and a negligible one (AUC ratio below 1.25) for P-gp, using digoxin.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.