Fesoterodine Fumarate Rifampicin
ModerateRifampicin (rifampin) and carbamazepine are CYP3A4 inducers, meaning they speed up the enzyme that breaks down fesoterodine's active form. When rifampin 600 mg was taken once a day with Toviaz (fesoterodine) 8 mg, the peak level (Cmax) of the active metabolite fell by about 70%. The total amount of it in the blood over time (AUC) fell by about 75%. Even so, the leaflet says no dose change is recommended when a CYP3A4 inducer like rifampin is used.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.