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Community data Updated 23 hours ago

Fesoterodine Fumarate

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Indications

Adult Overactive Bladder Fesoterodine Fumarate is used to treat overactive bladder (OAB) in adults who have urge urinary incontinence, urgency and frequency. Pediatric Neurogenic Detrusor Overactivity Fesoterodine Fumarate is also used to treat neurogenic detrusor overactivity (NDO) in pediatric patients aged 6 years and older who weigh more than 25 kg.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Fesoterodine is a competitive muscarinic receptor antagonist. After you take it by mouth, the body quickly and extensively breaks it down with nonspecific esterases (a group of enzymes) into its active metabolite, 5-hydroxymethyl tolterodine. This metabolite is responsible for the antimuscarinic activity of fesoterodine. Muscarinic receptors play a role in the contractions of the urinary bladder smooth muscle. Blocking these receptors in the bladder is presumed to be how fesoterodine produces its effects.

A urodynamic study was carried out in patients with involuntary detrusor contractions. It assessed what happened to the volume at first detrusor contraction and to bladder capacity after fesoterodine was given. Both the volume at first detrusor contraction and the bladder capacity increased, and the increase depended on the dose. These findings are consistent with an antimuscarinic effect on the bladder.

Pregnancy & Breastfeeding

There are no data on the use of Fesoterodine in pregnant women and adolescents, so it isn't possible to judge whether the medicine carries a risk of major birth defects, miscarriage or other harmful outcomes for the mother or the baby.

Nothing is known about whether fesoterodine passes into human milk, what effect it has on a breastfed child, or whether it changes milk production. When deciding on Fesoterodine during breastfeeding, the benefits of breastfeeding for the baby's development and health should be weighed against the mother's own clinical need for the medicine. Any possible harmful effects on the breastfed child, either from Fesoterodine or from the mother's underlying condition, should be considered as well.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Overactive bladder in adults: the recommended starting dose of fesoterodine fumarate is 4 mg by mouth once daily. Depending on how the person responds and tolerates it, the dose can be raised to the maximum of 8 mg once daily. Neurogenic detrusor overactivity in pediatric patients 6 years and older: for pediatric patients weighing greater than 25 kg and up to 35 kg, the recommended dose is 4 mg by mouth once daily. If needed, it may be increased to 8 mg once daily. For pediatric patients weighing greater than 35 kg, the recommended starting dose is 4 mg by mouth once daily, and after one week it is increased to 8 mg once daily. Administration: swallow whole with liquid. Do not chew, divide, or crush. It can be taken with or without food. Pediatric use: the safety and effectiveness of Toviaz have been established for treating neurogenic detrusor overactivity (NDO) in pediatric patients aged 6 years and older and weighing greater than 25 kg. Geriatric use: no dose adjustment is recommended for the elderly. The pharmacokinetics of fesoterodine are not significantly influenced by age.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.