Suvorexant Rifampicin
ModerateRifampicin is a strong CYP3A inducer, and it can substantially lower the amount of suvorexant in the body. Suvorexant itself is unlikely to cause clinically significant inhibition of human CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19 or CYP2D6.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.