Indications
Suvorexant is used to treat insomnia, meaning trouble falling asleep, trouble staying asleep, or both.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Suvorexant is a highly selective antagonist of the orexin receptors OX1R and OX2R. It is presumed that Suvorexant works against insomnia by blocking these receptors. The orexin neuropeptide signaling system is a central promoter of wakefulness, and the two wake-promoting neuropeptides, orexin A and orexin B, normally bind to OX1R and OX2R. By blocking that binding, Suvorexant is thought to suppress the drive to stay awake.
Pregnancy & Breastfeeding
Suvorexant is Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women, so a doctor should prescribe it during pregnancy only if the likely benefit justifies the possible risk to the fetus.
It isn't known whether suvorexant passes into human milk. Many drugs are excreted in human milk, so caution is needed when suvorexant is given to a nursing woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.