Propafenone Hydrochloride Erythromycin
ModeratePropafenone is broken down in the body by enzymes called CYP2D6, CYP1A2 and CYP3A4, and several other medicines can slow those enzymes down. Erythromycin is one of them. When it is taken with propafenone, it can be expected to raise the level of propafenone in the blood. Grapefruit juice and a few other medicines (such as ketoconazole and ritonavir) do the same thing through CYP3A4.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.