Taking Venetoclax together with efavirenz should be avoided. Efavirenz is a moderate CYP3A inducer, which means it speeds up how the body breaks down Venetoclax, so the medicine may not work as well. The leaflet lists other medicines in the same group, but for efavirenz the advice is simply to avoid the combination.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.