Hertin Plus Lapatinib Digoxin
ModerateTaking lapatinib and digoxin together can raise the level of digoxin in the body. In one study, the amount of an oral digoxin dose reaching the bloodstream (the AUC) went up about 2.8-fold when lapatinib was taken as well. Digoxin is a P-gp substrate.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.