Sotorasib can raise the amount of digoxin in your blood. This happens because Sotorasib affects a protein in the body called P-glycoprotein, which normally helps clear digoxin out. With more digoxin left in the blood, the side effects of digoxin can become more likely or stronger.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.