Mizotic 15 Midazolam Treosulfan
ModerateModelling based on the body's physiology (PBPK modelling) was run using midazolam, omeprazole and digoxin as sensitive markers for the enzymes CYP3A4 and CYP2C19 and for the transporter P-gp. The model predicted a weak interaction with Treosulfan for CYP3A4 and CYP2C19, with an AUC ratio of 1.25 or more but less than 2. For P-gp, the interaction was predicted to be negligible, with an AUC ratio below 1.25.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.