Zybex SR Bupropion Hydrochloride Phenytoin Sodium
ModeratePhenytoin can lower the level and effect of bupropion in the body, since bupropion is one of the CYP2B6 substrates the leaflet lists. The leaflet gives no other detail or advice for this pair.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.