Pricing
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All price changes →Indications & Uses
Zybex SR is indicated for:
Pharmacology
Bupropion selectively blocks the re-uptake of catecholamines (noradrenaline and dopamine) in neurons. It has minimal effect on the re-uptake of indolamines (serotonin), and it does not inhibit monoamine oxidase. Like other antidepressants, its exact mechanism of action is unknown, but the effect is presumed to come from noradrenergic and/or dopaminergic mechanisms.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual adult target dose of Bupropion is 300 mg/day, given as 150 mg twice daily. Treatment should begin at 150 mg/day, taken as a single dose in the morning. If the patient tolerates this starting dose well enough, the dose may be raised to the 300 mg/day target (150 mg twice daily) as early as day 4. Leave an interval of at least 8 hours between doses.
Increasing the dosage above 300 mg/day
As with other antidepressants, the full effect of Bupropion Hydrochloride may not show until 4 weeks of treatment or longer. For patients who have had no clinical improvement after several weeks at 300 mg/day, an increase to the maximum of 400 mg/day, given as 200 mg twice daily, may be considered. Bupropion Hydrochloride should be stopped in patients who don't show an adequate response after an appropriate period of treatment at 450 mg/day.
Maintenance
The lowest dose that keeps the patient in remission is recommended. Nobody knows exactly how long a patient should stay on Bupropion Hydrochloride, but it is generally recognised that acute episodes of depression need several months or longer of antidepressant treatment.
Child and adolescent
Not recommended for children and adolescents under 18 years of age.
Side Effects
Agitation, anxiety and insomnia are common in the early stages of treatment with Bupropion Hydrochloride. Other fairly common side effects include fever, dry mouth, headache or migraine, dizziness, nausea and vomiting, constipation, tremor, sweating and skin rashes. Hypersensitivity reactions have also been reported, ranging from pruritus and urticaria to, less commonly, angio-oedema, dyspnoea and anaphylactoid reactions.
Cautions & Contraindications
Warnings & Precautions
Bupropion Hydrochloride needs extreme caution in patients with a history of seizure disorders, and in those with other predisposing factors such as severe hepatic cirrhosis or a CNS tumour. The same caution applies to people going through abrupt withdrawal from alcohol or Benzodiazepines. Some patients have other risk factors for seizures, for example alcohol abuse, a history of head trauma, diabetes, or drugs known to lower the seizure threshold. In these patients Bupropion Hydrochloride should only be given when there are compelling clinical reasons. Use it with caution in patients with bipolar depression or psychoses, in those with a recent history of myocardial infarction or unstable heart disease, and in hepatic or renal impairment.
Contraindications
Bupropion Hydrochloride must not be given to patients with a seizure disorder. It can induce seizures, so it is also contraindicated in patients with epilepsy. It must not be used with other medicines that contain Bupropion either, because the chance of seizure depends on the dose. The drug is also contraindicated in patients with a current or past diagnosis of bulimia or anorexia nervosa. A higher rate of seizures was seen in patients treated with Bupropion Hydrochloride for bulimia. Taking Bupropion Hydrochloride together with a monoamine oxidase (MAO) inhibitor is contraindicated. After an MAO inhibitor is stopped, at least 14 days should pass before treatment with Bupropion Hydrochloride begins. It is also contraindicated in patients who have shown an allergic response to Bupropion or to any of the other ingredients in Bupropion Hydrochloride.
Pregnancy & Breastfeeding
Bupropion is Pregnancy Category C. There are no adequate and well controlled studies in pregnant women, so the medicine should be used during pregnancy only if it is clearly needed.
Bupropion and its metabolites pass into human milk. Because of this, a decision has to be made whether to stop breast feeding or to stop the medicine.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Bupropion Hydrochloride below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Zybex SR 150 mg
What is Zybex SR 150 mg Tablet (Sustained Release)?
Zybex SR 150 mg Tablet (Sustained Release) is a medicine that contains Bupropion Hydrochloride. It is made by Beximco Pharmaceuticals Ltd. It belongs to the Atypical anti-depressant drugs group of medicines.
What is Zybex SR used for?
Zybex SR is used for: Depression.
What are the side effects of Zybex SR?
Agitation, anxiety and insomnia are common in the early stages of treatment with Bupropion Hydrochloride. Other fairly common side effects include fever, dry mouth, headache or migraine, dizziness, nausea and vomiting, constipation, tremor, sweating and skin rashes.
Can I take Zybex SR during pregnancy or while breastfeeding?
Bupropion is Pregnancy Category C. There are no adequate and well controlled studies in pregnant women, so the medicine should be used during pregnancy only if it is clearly needed. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Zybex SR?
Store Bupropion Hydrochloride below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Zybex SR?
Some medicines can interact with Bupropion Hydrochloride, for example: Carbamazepine, Theophylline, Cyclophosphamide, Cimetidine, Ifosfamide, Ritonavir. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Zybex SR is already among the lowest-priced brands of Bupropion Hydrochloride at this strength.
Do I need a prescription for Zybex SR?
Zybex SR is a prescription (Rx) medicine. Take it as your doctor advises.