Rymin Diphenhydramine Hydrochloride Polymyxin B Sulfate
MajorTaking Polymyxin B together with other medicines that can harm the nerves or kidneys should be avoided. Diphenhydramine is one of the medicines on that list, so it should not be taken alongside Polymyxin B. The list also includes many other antibiotics, pain relievers, and several more medicines, and the same advice applies to all of them.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.