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Polymyxin B Sulfate

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Indications

Polymyxin B Sulfate is a drug of choice for acute infections of the urinary tract, meninges and bloodstream caused by susceptible strains of Pseudomonas aeruginosa. It may also be indicated in serious infections caused by susceptible strains of some other organisms, when less potentially toxic drugs are ineffective or contraindicated. These are H. influenzae (specifically meningeal infections), Escherichia coli (specifically urinary tract infections), Aerobacter aerogenes (specifically bacteremia) and Klebsiella pneumoniae (specifically bacteremia).

⚠️ Always consult a registered physician before taking any medicine.

Pregnancy & Breastfeeding

No controlled data exist on the use of Polymyxin B Sulfate in human pregnancy, so its safety during pregnancy has not been established. There is also no recommendation about using it while breastfeeding, and no study has looked at whether it passes into human milk.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: For intravenous use, dissolve Polymyxin B 500,000 units in 300 to 500 ml of solutions for parenteral use, Dextrose injection 5%, and give it as a continuous drip. For intramuscular use, dissolve Polymyxin B 500,000 units in 2 ml of 0.9% Sodium Chloride solution. This route is not recommended routinely because of severe pain at the injection site, particularly in infants and children. For intrathecal use, dissolve Polymyxin B 500,000 units in 10 ml of 0.9% Sodium Chloride solution, which gives a dosage unit of 50,000 units per ml. In meningeal infections, Polymyxin B Sulfate should be given only by the intrathecal route. For the IV route, adults and children with normal kidney function get a dose of 15,000 to 25,000 units/kg/day, and this should not exceed 25,000. The dosage frequency and duration is that infusions may be given every 12 hours over a period of approximately 60 to 90 minutes. Adults and children with renal impairment get a dose of less than 15,000 units/kg/day, with the same dosage frequency and duration, so infusions may be given every 12 hours over approximately 60 to 90 minutes. Infants with normal kidney function get a maximum of 40,000 units/kg/day. For the IM route, adults and children get a dose of 25,000 to 30,000 units/kg/day. On dosage frequency and duration, the dose should be reduced in the presence of renal impairment. The dosage may be divided and given at either 4 or 6 hour intervals. Infants with normal kidney function get a maximum of 40,000 units/kg/day. For the intrathecal route, children under 2 years of age have a dosage frequency and duration of 20,000 units once daily, given intrathecally for 3 to 4 days, or 25,000 units once every other day. Continue with 25,000 units once every other day for at least 2 weeks after cultures of the cerebrospinal fluid are negative and the sugar content has returned to normal. Adults and children over 2 years of age get 50,000 units once daily for 3 to 4 days, then 50,000 units once every other day for at least 2 weeks after cultures of the cerebrospinal fluid are negative and the sugar content has returned to normal.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.