Topril Captopril Gliclazide
ModerateCaptopril, an ACE inhibitor (enalapril is another), can strengthen the blood-sugar-lowering effect of gliclazide. The leaflet lists it among the medicines that can do this, along with H2 receptor antagonists, which is a group of medicines for stomach and duodenal ulcers. This can lead to low blood sugar when the two are taken together.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.