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Other brands with the same active ingredient
These brands contain the same active ingredient (Captopril). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Topril
Other strengths and forms by Jayson Pharmaceuticals Ltd.
Indications & Uses
Topril is indicated for:
Pharmacology
Captopril is a sulfhydryl-containing analog of proline that works as an antihypertensive. It blocks angiotensin-converting enzyme (ACE), which lowers levels of angiotensin II, raises plasma renin activity, and reduces aldosterone secretion. In fasting healthy individuals or hypertensive patients, about 60-75% of an oral dose is absorbed quickly from the GI tract. Over 95% of the dose is eliminated by the kidneys, partly as unchanged drug (45-50%) and partly as metabolites.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Mild to moderate hypertension: The starting dose is 12.5 mg twice daily. The usual maintenance dose is 25 mg twice daily. This may be increased step by step, at intervals of two to four weeks, until a satisfactory response is reached, up to a maximum of 50 mg twice daily.
Severe hypertension: The starting dose is 12.5 mg twice daily. The dose may be increased step by step to a maximum of 50 mg three times daily.
Heart failure: A starting dose of 6.25 mg or 12.5 mg may reduce the brief drop in blood pressure that can occur at first. The usual maintenance dose is 25 mg three times a day. The usual maximum dose is 150 mg daily.
Captopril must be taken 1 hour before meals to ensure maximum absorption.
Use in children: Safety and effectiveness in paediatric patients have not been established.
Side Effects
Side effects may include low white blood cell count, anaemia, protein in the urine, low blood pressure, fast heartbeat, and rashes, which are usually itchy. Stomach irritation and abdominal pain may also occur.
Cautions & Contraindications
Warnings & Precautions
Kidney function should be checked before starting Acetor and at suitable intervals during treatment. Acetor should not normally be given to patients with impaired kidney function, and it should not be used in patients with aortic stenosis or obstruction of the heart's outflow tract.
Contraindications
Captopril should not be used by anyone who has previously had a hypersensitivity reaction to it. It is contraindicated in pregnancy, and women who could become pregnant should not take it unless they are using effective contraception.
Pregnancy & Breastfeeding
No data exist on use in pregnant women, so the drug's risk cannot be confirmed. Because serious reactions may occur in a nursing infant, a decision should be made either to stop breastfeeding or to stop the medicine.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
The main concern is to correct the hypertension.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Captopril below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Topril 25 mg
What is Topril 25 mg Tablet?
Topril 25 mg Tablet is a medicine that contains Captopril. It is made by Jayson Pharmaceuticals Ltd. It belongs to the Angiotensin-converting enzyme (ACE) inhibitors group of medicines.
What is Topril used for?
Topril is used for: Hypertension, Heart Failure.
What are the side effects of Topril?
Side effects may include low white blood cell count, anaemia, protein in the urine, low blood pressure, fast heartbeat, and rashes, which are usually itchy. Stomach irritation and abdominal pain may also occur.
Can I take Topril during pregnancy or while breastfeeding?
No data exist on use in pregnant women, so the drug's risk cannot be confirmed. Because serious reactions may occur in a nursing infant, a decision should be made either to stop breastfeeding or to stop the medicine. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Topril?
The main concern is to correct the hypertension. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Topril?
Store Captopril below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Topril?
Some medicines can interact with Captopril, for example: Aliskiren, Lithium Carbonate, Gliclazide, Benzoic Acid + Salicylic Acid. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Topril?
Topril is a prescription (Rx) medicine. Take it as your doctor advises.