Lopera-S Loperamide + Simethicone Desmopressin Acetate
ModerateTaking loperamide with simethicone alongside oral desmopressin can raise the amount of desmopressin in the blood about 3 fold. This is probably because the medicine moves more slowly through the gut. Drugs with similar effects may add to loperamide's action, while drugs that speed up the gut may weaken it.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.