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Desmopressin Acetate

Synthetic analogue of ADH Prescription
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Indications

Diabetes Mellitus

Desmopressin Acetate film coated tablets are used as antidiuretic replacement therapy in the management of central diabetes insipidus. They are also used to manage the temporary polyuria and polydipsia that follow head trauma or surgery in the pituitary region. The tablets are ineffective for the treatment of nephrogenic diabetes insipidus. Nocpres film coated tablets are indicated in exactly the same way, and they too are ineffective for nephrogenic diabetes insipidus. The Desmopressin Acetate sublingual tablet is used for the treatment of primary nocturnal enuresis, nocturia and central diabetes insipidus.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Desmopressin copies the action of the body's own ADH. It acts as a selective agonist at the V2 receptors in the renal collecting duct (CD), so the kidneys take back more water and make less urine. In patients with hemophilia and von Willebrand's disease Type I, desmopressin has been shown to raise plasma levels of factor VIII activity more than ADH does. Its pressor activity is markedly diminished. Given intranasally, desmopressin has an antidiuretic effect of about one-tenth that of an equivalent dose given by injection. Upon binding to the V2 receptors in the basolateral membrane of the cells of the distal tubule and collecting ducts of the nephron, adenylyl cyclase is stimulated. The intracellular cascades that follow in the collecting duct increase the rate at which water channels, called aquaporins, are inserted into the lumenal membrane, and the membrane becomes more permeable to water.

Pregnancy & Breastfeeding

No controlled studies have been done in nursing mothers, so doctors should take care when giving desmopressin acetate to a woman who is breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Desmopressin Acetate sublingual tablet is used for the treatment of diabetes insipidus. The dose is individual in this condition, but the total daily sublingual dose normally lies between 120 micrograms and 720 micrograms. A suitable starting dose in adults and children is 60 micrograms three times daily, taken sublingually. The doctor then adjusts this according to how the patient responds. For most patients, the maintenance dose is 60 micrograms to 120 micrograms sublingually three times daily. In post-hypophysectomy polyuria/polydipsia, the dose of Desmopressin Acetate Melt should be controlled by measuring urine osmolality. For the film coated tablet in adults and children, patients should be started on 0.05 mg (1/2 of the 0.1 mg tablet) two times a day. The dose is then adjusted for each person until the best therapeutic dose is reached. Most patients in clinical trials found the best dosage range was 0.1 mg to 0.8 mg daily, given in divided doses. Each dose should be adjusted separately so that the body's water turnover keeps an adequate diurnal rhythm. The total daily dosage should be increased or decreased within the range of 0.1 mg to 1.2 mg, divided into two or three daily doses, as needed to get adequate antidiuresis. For geriatric use, this medicine is known to be substantially excreted by the kidney, and the risk of toxic reactions may be greater in patients with impaired renal function. Elderly patients are more likely to have decreased renal function, so care should be taken in choosing the dose, and it may be useful to monitor renal function.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.