Tagrisso Osimertinib Ondansetron
MajorBoth prolong the QT interval; additive risk of torsades de pointes.
These medicines can affect each other in a serious way. Do not start taking them together unless your doctor has said it is OK. If you already take both, do not stop either one on your own: speak to your doctor or pharmacist soon.
Clinical management: Monitor ECG and electrolytes; correct potassium and magnesium; use lowest ondansetron dose.