Ondansetron

Adults: Chemotherapy-induced nausea and vomiting, adults and pediatric patients (6 months to 18 years): 8 mg tablet or orodispersible tablet: three doses of 0.15 mg/kg, up to a maximum of 16 mg per dose. 4 mg orodispersible tablet: three doses of 0.15 mg/kg, up to a maximum of 16 mg per dose. Injection: three doses of 0.15 mg/kg, up to a maximum of 16 mg per dose, infused intravenously over 15 minutes. Radiotherapy-induced nausea and vomiting, adults: 8 mg tablet or orodispersible tablet: the first dose is 8 mg by mouth 1 to 2 hours before radiotherapy. After radiotherapy, give 8 mg by mouth every 8 hours for up to 5 days after a course of treatment. 4 mg orodispersible tablet: three doses of 0.15 mg/kg, up to a maximum of 16 mg per dose. Injection: three doses of 0.15 mg/kg, up to a maximum of 16 mg per dose, infused intravenously over 15 minutes. Postoperative nausea and vomiting, adults: 8 mg tablet or orodispersible tablet: 16 mg, given as two 8 mg tablets. 4 mg orodispersible tablet: 16 mg. Injection: 4 mg. Pediatrics (over 40 kg), injection: 4 mg. Pediatrics (40 kg), injection: 0.1 mg/kg. Chemotherapy-induced nausea and vomiting, adults, geriatric patients and children of 12 years or over (oral solution): For highly emetogenic cancer chemotherapy, give 30 ml (24 mg) of Ondansetron Oral Solution 30 minutes before the chemotherapy starts. For moderately emetogenic cancer chemotherapy, give 10 ml (8 mg) of Ondansetron Oral Solution 30 minutes before the chemotherapy starts. A further 10 ml dose should be given 8 hours after the first dose. Then give one 10 ml dose twice a day (every 12 hours) for 1 to 2 days after the chemotherapy is finished. Pediatric patients (4 to 11 years): 5 ml (4 mg) of Ondansetron Oral Solution should be taken 30 minutes before chemotherapy starts. The other 2 doses should be taken 4 and 8 hours after the first dose. After that, give 5 ml of the oral solution 3 times a day (every 8 hours) for 1 to 2 days after the chemotherapy is finished. Radiotherapy-induced nausea and vomiting, oral solution (adults, geriatric patients and children of 12 years or over): The recommended oral dose is 10 ml (8 mg) of Ondansetron Oral Solution 3 times daily. For total body irradiation, give 10 ml (8 mg) of Ondansetron Oral Solution 1 to 2 hours before each fraction of radiotherapy given each day. For single high-dose fraction radiotherapy to the abdomen, give one 10 ml dose of Ondansetron Oral Solution 1 to 2 hours before radiotherapy. Later doses follow every 8 hours after the first dose, for 1 to 2 days after radiotherapy is completed. For daily fractionated radiotherapy to the abdomen, give 10 ml (8 mg) of Ondansetron Oral Solution 1 to 2 hours before radiotherapy. Later doses follow every 8 hours after the first dose, for each day radiotherapy is given. Postoperative nausea and vomiting, oral solution (adults, geriatric patients and children of 12 years or over): Give 20 ml (16 mg) of Ondansetron Oral Solution 1 hour before induction of anesthesia. Oral soluble film: To prevent nausea and vomiting with highly emetogenic cancer chemotherapy, the adult oral dose is 24 mg, given one after another as three 8 mg films, 30 minutes before chemotherapy starts. To prevent nausea and vomiting with moderately emetogenic cancer chemotherapy: Adults and pediatric patients 12 years of age and older take one 8 mg film 30 minutes before chemotherapy, followed by an 8 mg dose 8 hours later. Then give one 8 mg film twice a day (every 12 hours) for 1 to 2 days after the chemotherapy is finished. Pediatric patients 4 through 11 years of age take one 4 mg film three times a day. The first dose goes 30 minutes before chemotherapy, with later doses 4 and 8 hours after that. Then give one 4 mg film three times a day (every 8 hours) for 1 to 2 days after the chemotherapy is finished. To prevent nausea and vomiting with radiotherapy, the adult dose is one 8 mg film three times a day. Postoperative nausea and vomiting: the adult dose is 16 mg, given one after another as two 8 mg films, 1 hour before anesthesia.