Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 23 hours ago

Indications

Zuclopenthixol is used to manage the symptoms of schizophrenia. It is meant for the first treatment of an acute psychotic episode, or when the psychosis that comes with schizophrenia gets worse.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Zuclopenthixol is a thioxanthene derivative. It binds strongly to both dopamine D1 and dopamine D2 receptors, and it also has a high affinity for α1-adrenergic and 5 HT2 receptors. Its blocking activity at histamine H1 receptors is weaker. Its affinity for muscarinic cholinergic and α2-adrenergic receptors is lower still.

Pregnancy & Breastfeeding

Nobody has shown that zuclopenthixol is safe to use during pregnancy. It passes into human breast milk, and its safety during breastfeeding hasn't been established either.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Zuclopenthixol tablets: when treatment starts, the medicine is best given in divided doses, either BID or TID. Once the patient is on maintenance treatment, the tablets may be given as a single dose at night. For acute psychosis, the usual starting dose is 10 to 50 mg/day. This can be raised by 10 to 20 mg every 2 to 3 days, depending on how the patient responds. The usual therapeutic range is 20 mg to 60 mg daily. As with other antipsychotic drugs, though, some patients need a lower dose and others need a higher one to get the best benefit. A daily dose above 100 mg is not recommended. For maintenance therapy, bring the dose down to the lowest level that still keeps symptoms under control. The usual maintenance dose is 20 to 40 mg/day. Zuclopenthixol Acuphase: adjust the dose for each patient according to their condition. The usual dose is 50 to 150 mg (1 to 3 ml), given by intramuscular injection and repeated if needed at intervals of 2 to 3 days. Some patients may need one more injection 1 or 2 days after the first. Zuclopenthixol Depot: the patient needs close supervision after Zuclopenthixol Depot is started, to lower the risk of over-medication or of psychotic symptoms not being suppressed enough. During this period, extra oral antipsychotic medicine may be needed in diminishing doses. The usual maintenance dose is 150 to 300 mg intramuscularly, every 2 to 4 weeks. Some patients may need higher or lower doses, or shorter intervals between doses.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.