Pricing
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All price changes →Indications & Uses
Zentixol A is indicated for:
Pharmacology
Zuclopenthixol is a thioxanthene derivative. It binds strongly to both dopamine D1 and dopamine D2 receptors, and it also has a high affinity for α1-adrenergic and 5 HT2 receptors. Its blocking activity at histamine H1 receptors is weaker. Its affinity for muscarinic cholinergic and α2-adrenergic receptors is lower still.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Zuclopenthixol tablets: when treatment starts, the medicine is best given in divided doses, either BID or TID. Once the patient is on maintenance treatment, the tablets may be given as a single dose at night. For acute psychosis, the usual starting dose is 10 to 50 mg/day. This can be raised by 10 to 20 mg every 2 to 3 days, depending on how the patient responds. The usual therapeutic range is 20 mg to 60 mg daily. As with other antipsychotic drugs, though, some patients need a lower dose and others need a higher one to get the best benefit. A daily dose above 100 mg is not recommended. For maintenance therapy, bring the dose down to the lowest level that still keeps symptoms under control. The usual maintenance dose is 20 to 40 mg/day.
Zuclopenthixol Acuphase: adjust the dose for each patient according to their condition. The usual dose is 50 to 150 mg (1 to 3 ml), given by intramuscular injection and repeated if needed at intervals of 2 to 3 days. Some patients may need one more injection 1 or 2 days after the first.
Zuclopenthixol Depot: the patient needs close supervision after Zuclopenthixol Depot is started, to lower the risk of over-medication or of psychotic symptoms not being suppressed enough. During this period, extra oral antipsychotic medicine may be needed in diminishing doses. The usual maintenance dose is 150 to 300 mg intramuscularly, every 2 to 4 weeks. Some patients may need higher or lower doses, or shorter intervals between doses.
Side Effects
Zuclopenthixol can cause a racing heart (tachycardia) and palpitations, which is the feeling of the heart beating rapidly, forcefully or irregularly. Tremor is also common. So is dystonia, where sustained muscle contractions cause twisting or repetitive movements or abnormal postures, and hypertonia, which means increased muscle stiffness.
Cautions & Contraindications
Warnings & Precautions
Take care with Zuclopenthixol if you have used it or any other treatment for schizophrenia before and had any problems with it. Be careful too if you are taking any other prescription or non-prescription medicines, if you are pregnant or thinking of becoming pregnant, or if you are breast-feeding. Tell your doctor if you regularly drink a lot of alcohol. The same applies if you have any liver problems, Parkinson's disease, or have ever had seizures. Caution is also needed if you have dementia, glaucoma or any kidney problems. Risk factors for stroke (e.g. smoking, high blood pressure) call for care as well. So do hypokalemia or hypomagnesia (too little potassium or magnesium in your blood) and a history of cardiovascular disorders. If you or someone in your family has a history of blood clots, mention that too. If you are being treated for cancer, caution is needed (this applies to Zuclopenthixol Depot only). Finally, take care if you use any other antipsychotic medicine.
Contraindications
Zuclopenthixol must not be given during acute intoxication with alcohol, barbiturates or opiates. It is also not for anyone with CNS depression from any cause, or in a comatose state. The same applies to patients with suspected or established subcortical brain damage, or circulatory collapse. People with known hypersensitivity to thioxanthenes or to zuclopenthixol itself should not take it, nor should anyone sensitive to any ingredient in the formulation or any component of the container.
Pregnancy & Breastfeeding
Nobody has shown that zuclopenthixol is safe to use during pregnancy. It passes into human breast milk, and its safety during breastfeeding hasn't been established either.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Zuclopenthixol hasn't been shown to be safe or effective in children under 18 years of age, so doctors don't recommend it for them.
Overdose
An overdose of zuclopenthixol may cause drowsiness (somnolence), coma, unusual movements, convulsions and shock. The person's body temperature may also become high or low.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Zuclopenthixol between 15°C and 25°C, and keep it away from light.
Drug Interactions
Common questions about Zentixol A 50 mg/ml
What is Zentixol A 50 mg/ml Injection?
Zentixol A 50 mg/ml Injection is a medicine that contains Zuclopenthixol. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Phenothiazine related drugs group of medicines.
What is Zentixol A used for?
Zentixol A is used for: Schizophrenia.
What are the side effects of Zentixol A?
Zuclopenthixol can cause a racing heart (tachycardia) and palpitations, which is the feeling of the heart beating rapidly, forcefully or irregularly. Tremor is also common.
Can I take Zentixol A during pregnancy or while breastfeeding?
Nobody has shown that zuclopenthixol is safe to use during pregnancy. It passes into human breast milk, and its safety during breastfeeding hasn't been established either. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Zentixol A?
An overdose of zuclopenthixol may cause drowsiness (somnolence), coma, unusual movements, convulsions and shock. The person's body temperature may also become high or low. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Zentixol A?
Store Zuclopenthixol between 15°C and 25°C, and keep it away from light.
Can I take other medicines with Zentixol A?
Some medicines can interact with Zuclopenthixol, for example: Moxifloxacin, Levodopa, Metoclopramide, Amiodarone Hydrochloride, Sotalol Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Zentixol A?
Zentixol A is a prescription (Rx) medicine. Take it as your doctor advises.