Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago
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Indications

Depression

Vortioxetine Hydrobromide is used to treat major depressive disorder (MDD) in adults.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Doctors don't fully understand how Vortioxetine works as an antidepressant. It is thought to raise serotonin activity in the central nervous system by blocking the reuptake of serotonin (5-HT). Vortioxetine also has several other actions, including 5-HT3 receptor antagonism and 5-HT1A receptor agonism.

Pregnancy & Breastfeeding

Nobody has established that Vortioxetine is safe in human pregnancy. So it should not be used during pregnancy, or by women who plan to become pregnant, unless the benefits outweigh the possible risks to the fetus.

Animal data show that Vortioxetine metabolites pass into milk, and the same is expected in human milk. Because a risk to the nursing child cannot be excluded, breastfeeding is not recommended while a mother is being treated with Vortioxetine.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Recommended dose The recommended starting dose of Vortioxetine is 10 mg taken by mouth once daily, with or without meals. The dose should then be increased to 20 mg/day, as tolerated. Doses above 20 mg/day have not been evaluated for efficacy and safety in controlled clinical trials. If a patient can't tolerate the higher doses, a decrease down to 5 mg/day may be considered. For elderly patients (>65 years of age), the lowest effective dose of 5 mg/day should always be used as the starting dose. Maintenance dose For MDD, Vortioxetine can be given for several months or longer. When a patient stays on it for a long period, the doctor should re-evaluate them from time to time to assess how useful the medicine is for that individual patient. Discontinuation treatment Vortioxetine can be stopped abruptly. Even so, in placebo-controlled trials, patients had transient adverse reactions such as headache and muscle tension after abruptly stopping Vortioxetine 15 mg/day or 20 mg/day. To avoid these reactions, the dose should be decreased to 10 mg/day for one week before Vortioxetine 15 mg/day or 20 mg/day is fully discontinued. Switching a patient to or from a Monoamine Oxidase Inhibitor (MAOI) intended to treat Psychiatric Disorders At least 14 days must pass between stopping an MAOI intended to treat psychiatric disorders and starting Vortioxetine, to avoid the risk of Serotonin Syndrome. In the other direction, at least 21 days must pass after stopping Vortioxetine before an MAOI intended to treat psychiatric disorders is started.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.