Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →More from Nytenso
Other strengths and forms by Incepta Pharmaceuticals Ltd.
Indications & Uses
Nytenso is indicated for:
Pharmacology
Doctors don't fully understand how Vortioxetine works as an antidepressant. It is thought to raise serotonin activity in the central nervous system by blocking the reuptake of serotonin (5-HT). Vortioxetine also has several other actions, including 5-HT3 receptor antagonism and 5-HT1A receptor agonism.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Recommended dose
The recommended starting dose of Vortioxetine is 10 mg taken by mouth once daily, with or without meals. The dose should then be increased to 20 mg/day, as tolerated. Doses above 20 mg/day have not been evaluated for efficacy and safety in controlled clinical trials. If a patient can't tolerate the higher doses, a decrease down to 5 mg/day may be considered. For elderly patients (>65 years of age), the lowest effective dose of 5 mg/day should always be used as the starting dose.
Maintenance dose
For MDD, Vortioxetine can be given for several months or longer. When a patient stays on it for a long period, the doctor should re-evaluate them from time to time to assess how useful the medicine is for that individual patient.
Discontinuation treatment
Vortioxetine can be stopped abruptly. Even so, in placebo-controlled trials, patients had transient adverse reactions such as headache and muscle tension after abruptly stopping Vortioxetine 15 mg/day or 20 mg/day. To avoid these reactions, the dose should be decreased to 10 mg/day for one week before Vortioxetine 15 mg/day or 20 mg/day is fully discontinued.
Switching a patient to or from a Monoamine Oxidase Inhibitor (MAOI) intended to treat Psychiatric Disorders
At least 14 days must pass between stopping an MAOI intended to treat psychiatric disorders and starting Vortioxetine, to avoid the risk of Serotonin Syndrome. In the other direction, at least 21 days must pass after stopping Vortioxetine before an MAOI intended to treat psychiatric disorders is started.
Side Effects
People taking Vortioxetine Hydrobromide may have side effects such as hypersensitivity, clinical worsening and suicide risk, serotonin syndrome, abnormal bleeding, activation of mania or hypomania, angle closure glaucoma and hyponatremia.
Cautions & Contraindications
Warnings & Precautions
Clinical worsening and suicide risk: anyone treated with an antidepressant, for any reason, should be monitored and watched closely for clinical worsening, suicidality and unusual changes in behaviour. This matters most during the first few months of treatment and whenever the dose is changed, whether it goes up or down. Serotonin syndrome: a potentially life-threatening serotonin syndrome has been reported with serotonergic antidepressants, Vortioxetine Hydrobromide among them. It can happen when the medicine is used alone, but more often when it is used together with other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone and St. John's Wort), and with drugs that impair the metabolism of serotonin. The main ones here are MAOIs, both those meant to treat psychiatric disorders and others such as linezolid and intravenous methylene blue. Abnormal bleeding: drugs that interfere with serotonin reuptake inhibition, including vortioxetine hydrobromide, may increase the risk of bleeding events. Taking aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), warfarin or other anticoagulants at the same time may add to this risk. Activation of mania or hypomania: as with all antidepressants, use vortioxetine hydrobromide with caution in patients who have a history or family history of bipolar disorder, mania or hypomania. Angle closure glaucoma: many antidepressants, this one included, cause the pupil to dilate, and this may trigger an angle closure attack in a patient with anatomically narrow angles who does not have a patent iridectomy. Hyponatremia: hyponatremia occurs because of treatment with serotonergic drugs.
Contraindications
Vortioxetine Hydrobromide must not be given to patients who are known to be hypersensitive to vortioxetine or to any of the excipients in the product. It must also not be used together with Monoamine Oxidase Inhibitors (MAOIs).
Pregnancy & Breastfeeding
Nobody has established that Vortioxetine is safe in human pregnancy. So it should not be used during pregnancy, or by women who plan to become pregnant, unless the benefits outweigh the possible risks to the fetus.
Animal data show that Vortioxetine metabolites pass into milk, and the same is expected in human milk. Because a risk to the nursing child cannot be excluded, breastfeeding is not recommended while a mother is being treated with Vortioxetine.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
In children and adolescents under 18 years of age, the safety and effectiveness of Vortioxetine Hydrobromide have not been established. For people over 65 years, no dose adjustment is recommended on the basis of age. A single-dose pharmacokinetic study compared elderly subjects (over 65 years old) with young subjects (24 to 45 years old), and the pharmacokinetics were generally similar in the two age groups.
If the patient has renal impairment, no dose adjustment is needed. In mild or moderate hepatic impairment, no dose adjustment is recommended either, but the medicine is not recommended in patients with severe hepatic impairment.
Among CYP2D6 poor metabolizers, the plasma concentration of Vortioxetine Hydrobromide was approximately two times higher than in extensive metabolizers. If a strong CYP3A4/2C9 inhibitor is also present, the exposure could potentially be higher, and a dosage adjustment may be required.
In other patient groups, no dose adjustment is needed on the basis of race, gender or ethnicity.
Overdose
We don't have much data on overdose with Vortioxetine Hydrobromide. If an overdose is suspected, the person should be followed up medically in a specialised setting.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Vortioxetine Hydrobromide at 30°C or below, in a dry place and away from light. Children should not be able to reach it, so keep it out of their reach.
Drug Interactions
Common questions about Nytenso 20 mg
What is Nytenso 20 mg Tablet?
Nytenso 20 mg Tablet is a medicine that contains Vortioxetine Hydrobromide. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Serotonin-norepinephrine reuptake inhibitor (SNRI) group of medicines.
What is Nytenso used for?
Nytenso is used for: Depression.
What are the side effects of Nytenso?
People taking Vortioxetine Hydrobromide may have side effects such as hypersensitivity, clinical worsening and suicide risk, serotonin syndrome, abnormal bleeding, activation of mania or hypomania, angle closure glaucoma and hyponatremia.
Can I take Nytenso during pregnancy or while breastfeeding?
Nobody has established that Vortioxetine is safe in human pregnancy. So it should not be used during pregnancy, or by women who plan to become pregnant, unless the benefits outweigh the possible risks to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Nytenso?
We don't have much data on overdose with Vortioxetine Hydrobromide. If an overdose is suspected, the person should be followed up medically in a specialised setting. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Nytenso?
Keep Vortioxetine Hydrobromide at 30°C or below, in a dry place and away from light. Children should not be able to reach it, so keep it out of their reach.
Can I take other medicines with Nytenso?
Some medicines can interact with Vortioxetine Hydrobromide, for example: Buspirone, Tramadol Hydrochloride, Carbamazepine, Paroxetine, Phenytoin, Rifampicin. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Nytenso is already among the lowest-priced brands of Vortioxetine Hydrobromide at this strength.
Do I need a prescription for Nytenso?
Nytenso is a prescription (Rx) medicine. Take it as your doctor advises.