Indications
Vonoprazan + Amoxicillin + Clarithromycin is a standard triple therapy regimen. Doctors use it to eradicate H. pylori in people with active chronic gastritis, duodenal ulcers and gastric ulcers.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Helicobacter pylori (H. pylori) is linked to the cause of gastritis and peptic ulcer. The standard triple therapy for clearing it is vonoprazan, amoxicillin and clarithromycin, taken by mouth as a 20 mg vonoprazan tablet, a 500 mg amoxicillin capsule and a 500 mg clarithromycin tablet. This regimen is effective for eradicating H. pylori.
Vonoprazan reduces both basal and stimulated gastric acid secretion. It works at the secretory surface of the gastric parietal cell, where it inhibits the H+ K+ -ATPase enzyme system in a potassium competitive manner. This enzyme is regarded as the acid (proton) pump of the parietal cell, so vonoprazan is described as a type of gastric proton-pump inhibitor, since it blocks the final step of acid production. It doesn't need acid to activate it. It may also concentrate selectively in the parietal cells, in both the resting and the stimulated state. Vonoprazan binds to the active proton pumps in a noncovalent and reversible way.
Amoxicillin is an antibacterial drug, and clarithromycin is a macrolide antimicrobial drug. Acid suppression increases the replication of H. pylori bacteria, and it also increases the stability and effectiveness of the antimicrobials in treating the infection.
Pregnancy & Breastfeeding
Animal studies and observational studies in pregnant women who took clarithromycin point to a risk, so this triple pack of vonoprazan, amoxicillin and clarithromycin is not recommended in pregnancy. The only exception is a clinical situation where no other treatment is appropriate.
For breastfeeding, there are no data on whether vonoprazan passes into human milk, what it does to a breastfed infant, or how it affects milk production. Vonoprazan and its metabolites are present in rat milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.