Indications & Uses
Vonoprazan + Amoxicillin + Clarithromycin is a standard triple therapy regimen. Doctors use it to eradicate H. pylori in people with active chronic gastritis, duodenal ulcers and gastric ulcers.
Pharmacology
Helicobacter pylori (H. pylori) is linked to the cause of gastritis and peptic ulcer. The standard triple therapy for clearing it is vonoprazan, amoxicillin and clarithromycin, taken by mouth as a 20 mg vonoprazan tablet, a 500 mg amoxicillin capsule and a 500 mg clarithromycin tablet. This regimen is effective for eradicating H. pylori.
Vonoprazan reduces both basal and stimulated gastric acid secretion. It works at the secretory surface of the gastric parietal cell, where it inhibits the H+ K+ -ATPase enzyme system in a potassium competitive manner. This enzyme is regarded as the acid (proton) pump of the parietal cell, so vonoprazan is described as a type of gastric proton-pump inhibitor, since it blocks the final step of acid production. It doesn't need acid to activate it. It may also concentrate selectively in the parietal cells, in both the resting and the stimulated state. Vonoprazan binds to the active proton pumps in a noncovalent and reversible way.
Amoxicillin is an antibacterial drug, and clarithromycin is a macrolide antimicrobial drug. Acid suppression increases the replication of H. pylori bacteria, and it also increases the stability and effectiveness of the antimicrobials in treating the infection.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended regimen for adults is vonoprazan 20 mg, amoxicillin 1000 mg and clarithromycin 500 mg. Each one is taken twice daily, in the morning and evening about 12 hours apart, with or without food, for 14 days.
Geriatrics: The standard triple therapy regimen carries an increased risk of torsade de pointes because of the clarithromycin component.
Renal Impairment: Avoid use in severe renal impairment.
Hepatic Impairment: Avoid use in moderate and severe hepatic impairment.
Side Effects
Side-effect information is not available for this brand yet.
Cautions & Contraindications
Warnings & Precautions
Hypersensitivity reactions: Serious and sometimes fatal reactions (anaphylaxis, for example) have been reported with the components of this Vonoprazan + Amoxicillin + Clarithromycin triple pack. If a hypersensitivity reaction happens, stop the pack and start treatment straight away, such as anaphylaxis management. Severe cutaneous adverse reactions (SCAR): Stop this pack at the first signs or symptoms of SCAR or other signs of hypersensitivity, and consider further evaluation. Clostridioides difficile-associated diarrhea (CDAD): If diarrhea occurs with this pack, it should be evaluated. Due to the clarithromycin component QT prolongation: Avoid this pack in patients with known QT prolongation, or in those receiving drugs known to prolong the QT interval, or with ventricular arrhythmia (torsades de pointes), hypokalemia/hypomagnesemia, or significant bradycardia, or in those taking Class IA or III antiarrhythmics. Hepatotoxicity: Stop the pack if signs and symptoms of hepatitis occur. Serious adverse reactions from use with other drugs: Serious adverse reactions can occur with this pack because clarithromycin interacts with colchicine, some lipid lowering agents, some calcium channel blockers, and other drugs. Embryo-fetal toxicity: Animal studies and human observational studies in pregnant women treated with clarithromycin point to a risk. For this reason the pack is not recommended in pregnant women, except where no alternative therapy is appropriate. Myasthenia gravis: This pack can make myasthenia gravis worse, since this has been reported in patients receiving clarithromycin tablets.
Contraindications
Don't give this triple therapy regimen to anyone with a known hypersensitivity to vonoprazan, to amoxicillin or any other betalactams, or to clarithromycin or any other macrolide antimicrobials.
Pregnancy & Breastfeeding
Animal studies and observational studies in pregnant women who took clarithromycin point to a risk, so this triple pack of vonoprazan, amoxicillin and clarithromycin is not recommended in pregnancy. The only exception is a clinical situation where no other treatment is appropriate.
For breastfeeding, there are no data on whether vonoprazan passes into human milk, what it does to a breastfed infant, or how it affects milk production. Vonoprazan and its metabolites are present in rat milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store below 30°C in a dry place. Protect from light, and keep out of the reach of children.
Drug Interactions
Common questions about Vonolend Kit 40 mg+2000 mg+1000 mg
What is Vonolend Kit 40 mg+2000 mg+1000 mg Tablet?
Vonolend Kit 40 mg+2000 mg+1000 mg Tablet is a medicine that contains Vonoprazan + Amoxicillin + Clarithromycin. It is made by Ziska Pharmaceuticals Ltd. It belongs to the Anti H. pylori drugs group of medicines.
What is Vonolend Kit used for?
Vonoprazan + Amoxicillin + Clarithromycin is a standard triple therapy regimen. Doctors use it to eradicate H.
Can I take Vonolend Kit during pregnancy or while breastfeeding?
Animal studies and observational studies in pregnant women who took clarithromycin point to a risk, so this triple pack of vonoprazan, amoxicillin and clarithromycin is not recommended in pregnancy. The only exception is a clinical situation where no other treatment is appropriate. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Vonolend Kit?
Store below 30°C in a dry place. Protect from light, and keep out of the reach of children.
Can I take other medicines with Vonolend Kit?
Some medicines can interact with Vonoprazan + Amoxicillin + Clarithromycin, for example: Cyclosporine, Cilostazol, Mycophenolate Mofetil, Itraconazole, Clopidogrel, Tacrolimus. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Vonolend Kit?
Vonolend Kit is a prescription (Rx) medicine. Take it as your doctor advises.