Informational only — Not medical advice. Always consult a licensed healthcare provider.

Shasthya স্বাস্থ্য · Health, made simple
বাং
Community data Updated 22 hours ago
🌐 বাংলায় দেখুন

Indications

Gastroesophageal Reflux Disease Peptic Ulcer Helicobacter Pylori Infection Cancer

Vonoprazan is used to treat gastric ulcer, duodenal ulcer and reflux esophagitis. It is also used to prevent a gastric or duodenal ulcer from coming back in people who are taking low-dose aspirin, and in people who are taking an NSAID. It is also given as an adjunct to Helicobacter pylori eradication in these conditions: gastric ulcer, duodenal ulcer, gastric mucosa-associated lymphatic tissue (MALT) lymphoma, idiopathic thrombocytopenic purpura, the stomach after endoscopic resection of early-stage gastric cancer, or Helicobacter pylori gastritis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Vonoprazan is a potassium competitive acid blocker (P-CAB), so it doesn't need acid to activate it. It blocks H+, K+-ATPase in a reversible way, competing with potassium. The medicine is strongly basic and stays for a long time at the acid production site of the gastric parietal cells, and this is how it reduces gastric acid production. Vonoprazan also has a strong inhibitory effect on the formation of mucosal damage in the upper part of the gastrointestinal tract.

Pregnancy & Breastfeeding

Vonoprazan should be given to a pregnant woman, or a woman who may be pregnant, only if the doctor thinks the expected benefit is greater than any possible risk. Nursing mothers are best advised to avoid vonoprazan. If it can't be avoided, breastfeeding should be stopped.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: For gastric ulcer and duodenal ulcer, the usual adult dose of Vonoprazan is 20 mg by mouth once daily. Treatment lasts 8 weeks for gastric ulcer and 6 weeks for duodenal ulcer. For reflux esophagitis, the usual adult dose is 20 mg once daily for a total of 4 weeks. If that isn't enough, treatment can be extended, but for no longer than 8 weeks. For maintenance therapy of reflux esophagitis showing recurrence and recrudescence, the oral dose is 10 mg once daily. When that doesn't work well enough, the dose may be increased up to 20 mg once daily. For prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin use, the usual adult dose is one 10 mg tablet taken orally once daily. The dose is the same for prevention of recurrence of gastric or duodenal ulcer during use of a non-steroidal anti-inflammatory drug (NSAID): one 10 mg tablet orally once daily. As an adjunct to Helicobacter pylori eradication, adults take a three-drug regimen orally at the same time, twice daily for seven days. The regimen is 20 mg of Vonoprazan, 750 mg of amoxicillin hydrate and 200 mg of clarithromycin. The clarithromycin dose may be increased as clinically warranted, but it should not go above 400 mg twice daily. If eradication with a three-drug regimen of a proton pump inhibitor, amoxicillin hydrate and clarithromycin has been unsuccessful, adults can be given an alternative treatment. They take three drugs orally twice daily for seven days: 20 mg of Vonoprazan, 750 mg of amoxicillin hydrate and 250 mg of metronidazole.