Pricing
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Xevon is indicated for:
Pharmacology
Vonoprazan is a potassium competitive acid blocker (P-CAB), so it doesn't need acid to activate it. It blocks H+, K+-ATPase in a reversible way, competing with potassium. The medicine is strongly basic and stays for a long time at the acid production site of the gastric parietal cells, and this is how it reduces gastric acid production. Vonoprazan also has a strong inhibitory effect on the formation of mucosal damage in the upper part of the gastrointestinal tract.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For gastric ulcer and duodenal ulcer, the usual adult dose of Vonoprazan is 20 mg by mouth once daily. Treatment lasts 8 weeks for gastric ulcer and 6 weeks for duodenal ulcer. For reflux esophagitis, the usual adult dose is 20 mg once daily for a total of 4 weeks. If that isn't enough, treatment can be extended, but for no longer than 8 weeks. For maintenance therapy of reflux esophagitis showing recurrence and recrudescence, the oral dose is 10 mg once daily. When that doesn't work well enough, the dose may be increased up to 20 mg once daily. For prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin use, the usual adult dose is one 10 mg tablet taken orally once daily. The dose is the same for prevention of recurrence of gastric or duodenal ulcer during use of a non-steroidal anti-inflammatory drug (NSAID): one 10 mg tablet orally once daily. As an adjunct to Helicobacter pylori eradication, adults take a three-drug regimen orally at the same time, twice daily for seven days. The regimen is 20 mg of Vonoprazan, 750 mg of amoxicillin hydrate and 200 mg of clarithromycin. The clarithromycin dose may be increased as clinically warranted, but it should not go above 400 mg twice daily. If eradication with a three-drug regimen of a proton pump inhibitor, amoxicillin hydrate and clarithromycin has been unsuccessful, adults can be given an alternative treatment. They take three drugs orally twice daily for seven days: 20 mg of Vonoprazan, 750 mg of amoxicillin hydrate and 250 mg of metronidazole.
Side Effects
These side effects have been reported in people using Vonoprazan: diarrhea, constipation, drug hypersensitivity (including anaphylactic shock), drug eruption, urticaria, hepatotoxicity, jaundice, rash, nausea and abdominal distension. Test results may also change, with increased gamma-glutamyl transferase, increased AST, abnormal liver function tests, increased ALT, increased ALP, increased LDH and increased y-GPT. Edema and eosinophilia have been reported as well.
Cautions & Contraindications
Warnings & Precautions
While treating a patient with Vonoprazan, watch how the disease is progressing and use the lowest dose that works for the condition. If Vonoprazan is given over a long period, the patient should be closely observed, for example by endoscopy. For maintaining healing of reflux esophagitis, give Vonoprazan only to patients whose condition keeps coming back or flaring up. Avoid giving it to patients who don't need maintenance of healing. When healing has been maintained for a long time and there is no risk of recurrence, consider lowering the dose from 20 mg to 10 mg, or stopping the medicine.
Contraindications
Vonoprazan must not be used in people who are hypersensitive to Vonoprazan or to any excipient in the product. It must also not be used in patients who are receiving atazanavir sulphate, nelfinavir or rilpivirine hydrochloride.
Pregnancy & Breastfeeding
Vonoprazan should be given to a pregnant woman, or a woman who may be pregnant, only if the doctor thinks the expected benefit is greater than any possible risk. Nursing mothers are best advised to avoid vonoprazan. If it can't be avoided, breastfeeding should be stopped.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Elderly patients: liver and kidney function usually decline with age, so Vonoprazan should be given with care.
Children under 18 years: The safety and efficacy of Vonoprazan have not been established in children and adolescents. For this reason it is not recommended for anyone below 18 years of age.
Renal impairment: Patients with mild to moderate renal impairment (eGFR 30 to 89 mL/min) need no dose adjustment. Avoid Vonoprazan if the renal impairment is severe (eGFR < 30 mL/min).
Hepatic impairment: No dose adjustment is recommended for mild hepatic impairment (Child-Pugh A). Avoid Vonoprazan in moderate to severe hepatic impairment (Child-Pugh B or C).
Overdose
No one has reported an overdose with Vonoprazan so far. Hemodialysis does not remove Vonoprazan from the blood, so it won't help in this case. If an overdose does happen, the treatment is symptomatic and supportive.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Vonoprazan below 30°C, in a cool and dry place, and away from light. Keep all the medicine out of the reach of children.
Common questions about Xevon 20 mg
What is Xevon 20 mg Tablet?
Xevon 20 mg Tablet is a medicine that contains Vonoprazan. It is made by Ibn Sina Pharmaceutical Ind. Ltd. It belongs to the Potassium competitive acid blocker group of medicines.
What is Xevon used for?
Xevon is used for: Gastroesophageal Reflux Disease, Peptic Ulcer, Helicobacter Pylori Infection, Cancer.
What are the side effects of Xevon?
These side effects have been reported in people using Vonoprazan: diarrhea, constipation, drug hypersensitivity (including anaphylactic shock), drug eruption, urticaria, hepatotoxicity, jaundice, rash, nausea and abdominal distension. Test results may also change, with increased gamma-glutamyl transferase, increased AST, abnormal liver function tests, increased ALT, increased ALP, increased LDH and increased y-GPT.
Can I take Xevon during pregnancy or while breastfeeding?
Vonoprazan should be given to a pregnant woman, or a woman who may be pregnant, only if the doctor thinks the expected benefit is greater than any possible risk. Nursing mothers are best advised to avoid vonoprazan. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Xevon?
No one has reported an overdose with Vonoprazan so far. Hemodialysis does not remove Vonoprazan from the blood, so it won't help in this case. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Xevon?
Keep Vonoprazan below 30°C, in a cool and dry place, and away from light. Keep all the medicine out of the reach of children.
Is there a cheaper medicine with the same ingredient?
Xevon is already among the lowest-priced brands of Vonoprazan at this strength.
Do I need a prescription for Xevon?
Xevon is a prescription (Rx) medicine. Take it as your doctor advises.