Vildagliptin + Metformin Hydrochloride
Indications
Vildagliptin + Metformin Hydrochloride tablet is used along with diet and exercise to improve blood sugar control in adults and other patients with type 2 diabetes mellitus. It is meant for patients whose diabetes is not well controlled on Metformin Hydrochloride alone or on Vildagliptin alone. It is also used for patients who already take Vildagliptin and Metformin Hydrochloride together as separate tablets.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Vildagliptin works mainly by blocking DPP-4 (Dipeptidyl peptidase-4), the enzyme that breaks down the incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). When Vildagliptin is given, DPP-4 activity is blocked quickly and completely. The body's own levels of GLP-1 and GIP then rise, both in the fasting state and after meals. With more of these incretin hormones available, Vildagliptin increases insulin secretion from the pancreatic beta cells and decreases glucagon secretion from the alpha cells. During hyperglycaemia, the higher incretin levels push the insulin/glucagon ratio up further. This lowers the liver's glucose production, fasting and after meals, and so glycaemia is reduced.
Metformin Hydrochloride is a biguanide type of oral antihyperglycemic drug, used in the management of type 2 diabetes. It lowers both basal and postprandial plasma glucose. Its mechanism of action is different from that of the sulfonylureas, and it does not produce hypoglycemia. Glucomin decreases hepatic glucose production and decreases the absorption of glucose from the intestine. It also improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Pregnancy & Breastfeeding
There aren't enough well controlled studies in pregnant women, so Vildagliptin + Metformin Hydrochloride should not be used during pregnancy unless the possible benefit justifies the possible risk to the foetus. No studies have been done with the individual components of this combination either. It is also not known whether Vildagliptin or Metformin Hydrochloride passes into human milk, so this combination should not be given to women who are breast-feeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.