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Same active ingredient — pay up to 32% less
These brands contain the same active ingredient (Vildagliptin + Metformin Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Vildamet
Other strengths and forms by Opsonin Pharma Limited
Indications & Uses
Vildamet is indicated for:
Pharmacology
Vildagliptin works mainly by blocking DPP-4 (Dipeptidyl peptidase-4), the enzyme that breaks down the incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). When Vildagliptin is given, DPP-4 activity is blocked quickly and completely. The body's own levels of GLP-1 and GIP then rise, both in the fasting state and after meals. With more of these incretin hormones available, Vildagliptin increases insulin secretion from the pancreatic beta cells and decreases glucagon secretion from the alpha cells. During hyperglycaemia, the higher incretin levels push the insulin/glucagon ratio up further. This lowers the liver's glucose production, fasting and after meals, and so glycaemia is reduced.
Metformin Hydrochloride is a biguanide type of oral antihyperglycemic drug, used in the management of type 2 diabetes. It lowers both basal and postprandial plasma glucose. Its mechanism of action is different from that of the sulfonylureas, and it does not produce hypoglycemia. Glucomin decreases hepatic glucose production and decreases the absorption of glucose from the intestine. It also improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults can start Vildagliptin + Metformin Hydrochloride twice a day, with 1 tablet in the morning and 1 in the evening. The doctor chooses this based on the Metformin dose the patient is already taking. If a patient takes Vildagliptin and Metformin as separate tablets, they can be switched to this combination tablet with the same dose of each component. Doses higher than 100 mg of vildagliptin are not recommended. There is no clinical experience of using Vildagliptin and Metformin in a triple combination with other antidiabetic agents. Taking the combination with food or just after food may reduce the gastrointestinal symptoms linked to Metformin.
Side Effects
The most common side effects of Vildagliptin + Metformin Hydrochloride are headache, tremor, dizziness, nausea, hypoglycaemia and so on.
Cautions & Contraindications
Warnings & Precautions
Lactic acidosis can occur because Metformin builds up in the body. If metabolic acidosis is suspected, stop the treatment and take the patient to hospital immediately. Serum creatinine should be checked at least once a year in patients with normal kidney function. In patients whose serum creatinine is at the upper limit of normal, and in elderly patients, it should be checked 2 to 4 times a year. Take special care in elderly patients, because their kidney function can become impaired (for example, when antihypertensives, diuretics or NSAIDs are started). Liver Function Tests (LFTs) are recommended before starting Vildagliptin + Metformin Hydrochloride, then at three-monthly intervals in the first year, and periodically after that. If transaminase levels are raised, do a second liver function test to confirm the finding, and keep following the patient with frequent liver function tests until the abnormality returns to normal. If AST or ALT stays at 3 x ULN, Vildagliptin & Metformin tablets should be stopped. The same applies to patients who develop jaundice or other signs of liver dysfunction. Once treatment has been withdrawn and the LFTs have returned to normal, Vildagliptin & Metformin should not be started again. Vildagliptin & Metformin tablets should be stopped 48 hours before elective surgery with general anaesthesia, and should not usually be restarted earlier than 48 hours afterwards.
Contraindications
Don't give Vildagliptin + Metformin Hydrochloride to anyone who is known to be hypersensitive to vildagliptin, metformin hydrochloride or any of the excipients. It is also contraindicated in patients with renal disease or renal dysfunction, acute myocardial infarction and septicaemia. The same applies to patients with congestive heart failure, and to those with acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma. The combination should be stopped temporarily in patients who are having radiologic studies that involve intravascular administration of iodinated contrast materials, because these products may cause an acute change in renal function.
Pregnancy & Breastfeeding
There aren't enough well controlled studies in pregnant women, so Vildagliptin + Metformin Hydrochloride should not be used during pregnancy unless the possible benefit justifies the possible risk to the foetus. No studies have been done with the individual components of this combination either. It is also not known whether Vildagliptin or Metformin Hydrochloride passes into human milk, so this combination should not be given to women who are breast-feeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Use in children: the safety and effectiveness of Vildagliptin + Metformin Hydrochloride have not been established in pediatric patients, so it is not recommended for children below 18 years of age. Use in elderly patients: Metformin is excreted through the kidney, and older people tend to have reduced renal function. Elderly patients taking this medicine should therefore have their renal function monitored regularly, and Vildagliptin + Metformin Hydrochloride should only be used in the elderly when renal function is normal. Patients with renal impairment: don't use it in renal failure or renal dysfunction, for example serum creatinine levels >1.5 mg/dl (>135 micro mol/L) in males and >1.4 mg/dl (>110 micro mol/L) in females. Patients with hepatic impairment: it is not recommended in hepatic impairment, including patients whose ALT or AST before treatment is >3 X the upper limit of normal.
Storage
Store Vildagliptin + Metformin Hydrochloride in a dry place, away from light and heat. Keep it out of children's reach.
Drug Interactions
Common questions about Vildamet 50 mg+500 mg
What is Vildamet 50 mg+500 mg Tablet?
Vildamet 50 mg+500 mg Tablet is a medicine that contains Vildagliptin + Metformin Hydrochloride. It is made by Opsonin Pharma Limited. It belongs to the Combination Oral hypoglycemic preparations group of medicines.
What is Vildamet used for?
Vildamet is used for: Type 2 Diabetes Mellitus, Diabetes Mellitus.
What are the side effects of Vildamet?
The most common side effects of Vildagliptin + Metformin Hydrochloride are headache, tremor, dizziness, nausea, hypoglycaemia and so on.
Can I take Vildamet during pregnancy or while breastfeeding?
There aren't enough well controlled studies in pregnant women, so Vildagliptin + Metformin Hydrochloride should not be used during pregnancy unless the possible benefit justifies the possible risk to the foetus. No studies have been done with the individual components of this combination either. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Vildamet?
Store Vildagliptin + Metformin Hydrochloride in a dry place, away from light and heat. Keep it out of children's reach.
Can I take other medicines with Vildamet?
Some medicines can interact with Vildagliptin + Metformin Hydrochloride, for example: Nifedipine, Furosemide. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Vildaglip M by Concord Pharmaceuticals Ltd. has the same ingredient and strength for ৳15.00 per unit, compared with ৳22.06 for Vildamet. Ask your doctor or pharmacist before switching.
Do I need a prescription for Vildamet?
Vildamet is a prescription (Rx) medicine. Take it as your doctor advises.