Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago
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Indications

Vardenafil is a medicine doctors prescribe for erectile dysfunction (ED).

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5). To see how it works, it helps to know how an erection happens. It is a hemodynamic process, and it starts when smooth muscle relaxes in the corpus cavernosum and in the small arterioles connected to it.

During sexual stimulation, nitric oxide is released in the corpus cavernosum. This activates the enzyme guanylate cyclase, and the smooth muscle cells of the corpus cavernosum then make more cyclic guanosine monophosphate (cGMP). The cGMP triggers the smooth muscle to relax, so more blood flows into the penis and an erection results.

By inhibiting PDE5, vardenafil raises the amount of cGMP and so improves erectile function. Nitric oxide is only released locally when there is sexual stimulation, so blocking PDE5 has no effect without it.

Pregnancy & Breastfeeding

Vardenafil is not meant for use by women.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The usual starting dose of Vardenafil is 10 mg once daily, taken by mouth about 60 minutes before sexual activity. Depending on how well it works and what side effects appear, the dose can be raised to a maximum of 20 mg or lowered to 5 mg. It should not be taken more than once a day. Vardenafil can be taken with or without food. Geriatrics: for patients over 65 years of age, a starting dose of 5 mg should be considered. Renal impaired patients: no dose adjustment is needed in patients with renal impairment. Hepatic impaired patients: in patients with moderate hepatic impairment, the recommended starting dose is 5 mg, and the maximum dose should not go above 10 mg. Vardenafil should not be used in patients with severe hepatic impairment.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.