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Indications & Uses
Vardenafil is a medicine doctors prescribe for erectile dysfunction (ED).
Pharmacology
Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5). To see how it works, it helps to know how an erection happens. It is a hemodynamic process, and it starts when smooth muscle relaxes in the corpus cavernosum and in the small arterioles connected to it.
During sexual stimulation, nitric oxide is released in the corpus cavernosum. This activates the enzyme guanylate cyclase, and the smooth muscle cells of the corpus cavernosum then make more cyclic guanosine monophosphate (cGMP). The cGMP triggers the smooth muscle to relax, so more blood flows into the penis and an erection results.
By inhibiting PDE5, vardenafil raises the amount of cGMP and so improves erectile function. Nitric oxide is only released locally when there is sexual stimulation, so blocking PDE5 has no effect without it.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual starting dose of Vardenafil is 10 mg once daily, taken by mouth about 60 minutes before sexual activity. Depending on how well it works and what side effects appear, the dose can be raised to a maximum of 20 mg or lowered to 5 mg. It should not be taken more than once a day. Vardenafil can be taken with or without food.
Geriatrics: for patients over 65 years of age, a starting dose of 5 mg should be considered.
Renal impaired patients: no dose adjustment is needed in patients with renal impairment.
Hepatic impaired patients: in patients with moderate hepatic impairment, the recommended starting dose is 5 mg, and the maximum dose should not go above 10 mg. Vardenafil should not be used in patients with severe hepatic impairment.
Side Effects
Vardenafil most often causes headache, flushing, and a stuffy or runny nose. Some people also get indigestion, an upset stomach, dizziness or back pain.
Cautions & Contraindications
Warnings & Precautions
Sexual activity puts some strain on the heart, so doctors should look at the cardiovascular condition of each patient before prescribing Vardenafil. If a man has been advised against sexual activity because of his underlying heart or circulation problem, Vardenafil generally should not be used.
Contraindications
Vardenafil must not be given together with nitrates, whether the nitrates are taken regularly or only now and then. The same applies to nitric oxide donors. The reason is that Vardenafil may increase the blood pressure lowering effect of nitrates. It is also contraindicated for patients who have shown hypersensitivity to Vardenafil or to any of the ingredients of this product.
Pregnancy & Breastfeeding
Vardenafil is not meant for use by women.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
The highest dose of Vardenafil with human data is a single 120 mg dose. Most of the people who took it had blurred vision and back pain. Single doses up to 80 mg, and multiple doses up to 40 mg taken once daily for 4 weeks, did not cause serious adverse effects. If an overdose happens, contact a doctor immediately.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Vardenafil at room temperature, away from light and moisture. Make sure children can't reach it.
Drug Interactions
Common questions about Vardena 10 mg
What is Vardena 10 mg Tablet?
Vardena 10 mg Tablet is a medicine that contains Vardenafil. It is made by Globe Pharmaceuticals Ltd. It belongs to the Drugs for Erectile Dysfunction group of medicines.
What is Vardena used for?
Vardenafil is a medicine doctors prescribe for erectile dysfunction (ED).
What are the side effects of Vardena?
Vardenafil most often causes headache, flushing, and a stuffy or runny nose. Some people also get indigestion, an upset stomach, dizziness or back pain.
Can I take Vardena during pregnancy or while breastfeeding?
Vardenafil is not meant for use by women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Vardena?
The highest dose of Vardenafil with human data is a single 120 mg dose. Most of the people who took it had blurred vision and back pain. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Vardena?
Keep Vardenafil at room temperature, away from light and moisture. Make sure children can't reach it.
Can I take other medicines with Vardena?
Some medicines can interact with Vardenafil, for example: Isosorbide Dinitrate + Hydralazine Hydrochloride, Erythromycin, Ritonavir, Ketoconazole. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Vardena is already among the lowest-priced brands of Vardenafil at this strength.
Do I need a prescription for Vardena?
Vardena is a prescription (Rx) medicine. Take it as your doctor advises.