Trimetazidine Dihydrochloride
Indications
Vastadin MR is used in adults as an add-on to first-line antianginal treatment. It is given to patients with stable angina pectoris whose symptoms are not adequately controlled by, or who cannot tolerate, those first-line therapies.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Trimetazidine Dihydrochloride was the first 3-keto acyl CoA thiolase inhibitor (KAT) developed, a metabolic anti-ischaemic agent shown to benefit all coronary patients. It works by inhibiting the 3-keto acyl CoA thiolase enzyme, which blocks the fatty acid pathway and shifts the heart's energy production toward the glucose pathway instead. Because the glucose pathway generates energy more efficiently, the same amount of oxygen yields more energy, helping the heart work more actively. The aerobic breakdown of glucose also halts the buildup of lactic acid, which helps prevent angina pectoris.
Pregnancy & Breastfeeding
There is no data on the use of trimetazidine in pregnant women. Animal studies have not shown any direct or indirect harmful effects on reproduction. Even so, as a precaution, it is better to avoid trimetazidine during pregnancy.
It is not known whether trimetazidine passes into human breast milk, and a risk to newborns and infants cannot be ruled out. For that reason, trimetazidine should not be taken while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.