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Community data Updated 2 months ago

Trifluoperazine

Phenothiazine drugs Prescription
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Indications

Nausea and Vomiting Depression Anxiety Schizophrenia

Anxiety states: Sizonil helps relieve excessive anxiety, tension, and agitation, whether occurring on its own (as in neuroses) or alongside physical illness. Nausea and vomiting: It is used to treat or prevent nausea and vomiting from various causes. Psychotic disorders: It is also used in the management of psychotic disorders, including acute or chronic catatonic, hebephrenic, and paranoid schizophrenia; psychosis resulting from organic brain damage; toxic psychosis; and the manic phase of manic-depressive illness.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Trifluoperazine belongs to the phenothiazine group of medicines, so it has a number of effects in the body. Some of these are the reason it works, and some are side effects. The most important action of phenothiazines is blocking dopamine receptors in the central nervous system (CNS). It is thought that this blocking in the limbic system and related parts of the cerebral cortex is what gives phenothiazines their antipsychotic effect. In the medullary chemoreceptor trigger zone, the same action seems to be responsible for their antiemetic effect, which is the ability to stop nausea and vomiting.

Pregnancy & Breastfeeding

Pregnancy: The safety of trifluoperazine in pregnancy has not been established. For this reason, it is not recommended for pregnant patients unless, in the physician's judgement, its use is essential, and the potential benefits clearly outweigh the possible risks. There have been reports of prolonged jaundice, extrapyramidal signs, and increased or decreased reflexes in newborn infants whose mothers received phenothiazines during pregnancy.

Breastfeeding: There is not enough human data available on the use of this medicine during breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Schizophrenia and other psychoses: Adults and children over 12 years: the recommended starting dose is 2 to 5 mg twice daily, increased by 5 mg daily after 1 week, then at intervals of 3 days according to response. Children (6 to 12 years): dosage should be adjusted to the weight of the child and the severity of the symptoms. The starting dosage is 1 mg twice daily. Dosage may be increased gradually until symptoms are controlled or until side effects become troublesome, though it is usually not necessary to exceed 15 mg daily. Elderly: reduce the initial dose by at least half. Short term management of severe anxiety: Adults and children over 12 years: 1 to 2 mg twice daily, increased if necessary to 6 mg daily. Children (3 to 5 years): 1 mg daily. Children (6 to 12 years): up to 4 mg daily in divided doses. Elderly: reduce the initial dose by at least half. Antiemetic: Adults: 2 to 4 mg daily in divided doses, maximum 6 mg daily. Children 3 to 5 years: up to 1 mg daily; 6 to 12 years: up to 4 mg daily.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.