Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 2 months ago

Indications

Doloran PRT is used to relieve moderate to severe pain, including pain after surgery, colic and spasm-related pain, cancer pain, joint pain, neck and back pain, and pain associated with osteoporosis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Tramadol is a synthetic pain reliever that works mainly in the central nervous system. It blocks the reabsorption of two natural chemical messengers, serotonin and noradrenaline, so their levels stay higher in the nerve pathways. This changes how pain signals are carried by acting on both the descending serotonergic and noradrenergic pathways involved in pain relief. Its pain-relieving effect also comes from stimulating mu-opioid receptors and indirectly adjusting the brain's own monoamine-based inhibitory pathways.

Pregnancy & Breastfeeding

Safe use during pregnancy has not been established. Tramadol is known to cross the placenta, and there are no adequate, well-controlled studies in pregnant women. For this reason, it should be used in pregnancy only if the expected benefit to the mother outweighs the potential risk to the unborn baby. Tramadol Hydrochloride should not be used while breastfeeding, since both the drug and its breakdown products pass into breast milk.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Capsule or Tablet The usual dose of Tramadol Hydrochloride is 50 to 100 mg every four to six hours. For acute pain, start with 100 mg. For chronic painful conditions, the recommended starting dose is 50 mg. After that, give 50 to 100 mg every 4 to 6 hours. How much you give and how often depends on how severe the pain is. The total daily dose by mouth should not go above 400 mg. Sustained Release Capsule or Tablet Take one SR capsule or tablet every 12 hours, for example the first in the morning and the next at the same time in the evening. The number of capsules taken at one time depends on the severity of the pain, but they should not be taken more often than every 12 hours. The total daily dose by mouth should not go above 400 mg. Injection A dose of 50 to 100 mg may be given every 4 to 6 hours, either by intramuscular injection or by intravenous infusion. For postoperative pain, the first dose is 100 mg, followed by 50 mg every 10 to 20 minutes if needed, up to a maximum of 250 mg in the first hour. After that, doses are 50 to 100 mg every 4 to 6 hours, up to a total daily dose of 600 mg. Suppository Tramadol suppositories are given rectally. For adults the usual dose is 100 mg of Tramadol Hydrochloride every 6 hours. In general, 400 mg per day (4 suppositories) is enough. For cancer pain and severe pain after operations, much higher daily doses can be used.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.