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These brands contain the same active ingredient (Tramadol Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Doloran
Other strengths and forms by Nevian Lifescience PLC
Indications & Uses
Doloran is indicated for:
Pharmacology
Tramadol is a synthetic pain reliever that works mainly in the central nervous system. It blocks the reabsorption of two natural chemical messengers, serotonin and noradrenaline, so their levels stay higher in the nerve pathways. This changes how pain signals are carried by acting on both the descending serotonergic and noradrenergic pathways involved in pain relief. Its pain-relieving effect also comes from stimulating mu-opioid receptors and indirectly adjusting the brain's own monoamine-based inhibitory pathways.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Capsule or Tablet
The usual dose of Tramadol Hydrochloride is 50 to 100 mg every four to six hours. For acute pain, start with 100 mg. For chronic painful conditions, the recommended starting dose is 50 mg. After that, give 50 to 100 mg every 4 to 6 hours. How much you give and how often depends on how severe the pain is. The total daily dose by mouth should not go above 400 mg.
Sustained Release Capsule or Tablet
Take one SR capsule or tablet every 12 hours, for example the first in the morning and the next at the same time in the evening. The number of capsules taken at one time depends on the severity of the pain, but they should not be taken more often than every 12 hours. The total daily dose by mouth should not go above 400 mg.
Injection
A dose of 50 to 100 mg may be given every 4 to 6 hours, either by intramuscular injection or by intravenous infusion. For postoperative pain, the first dose is 100 mg, followed by 50 mg every 10 to 20 minutes if needed, up to a maximum of 250 mg in the first hour. After that, doses are 50 to 100 mg every 4 to 6 hours, up to a total daily dose of 600 mg.
Suppository
Tramadol suppositories are given rectally. For adults the usual dose is 100 mg of Tramadol Hydrochloride every 6 hours. In general, 400 mg per day (4 suppositories) is enough. For cancer pain and severe pain after operations, much higher daily doses can be used.
Side Effects
Common side effects include dizziness, a spinning sensation (vertigo), nausea, constipation, headache, drowsiness, vomiting, itching, CNS stimulation, weakness, sweating, indigestion, dry mouth, and diarrhoea. Less commonly, it may cause malaise, allergic reaction, weight loss, vasodilatation, palpitations, abdominal pain, loss of appetite, flatulence, gastrointestinal bleeding, hepatitis, and mouth inflammation (stomatitis), among others.
Cautions & Contraindications
Warnings & Precautions
Respiratory depression: When large doses of tramadol are administered with anaesthetic medications or alcohol, respiratory depression may result. Therefore, tramadol should be administered cautiously in patients at risk for respiratory depression. Opioid dependence: Doloran PRT is not recommended for patients who are dependent on opioids. Concomitant CNS depressants: Doloran PRT should be used with caution and in reduced dosages when administering to patients receiving CNS depressants such as alcohol, opioids, anesthetic agents, phenothiazines, tranquilizers or sedative hypnotics. Concomitant MAO inhibitors: Doloran PRT should be used with great caution in patients taking MAO inhibitors, since tramadol inhibits the uptake of norepinephrine and serotonin. Doloran PRT should be used with caution in patients with increased intracranial pressure or head injury and patients with acute abdominal conditions.
Contraindications
Tramadol should not be used by anyone known to be hypersensitive to it. It should also be avoided during acute intoxication with alcohol, sleeping pills, other centrally acting painkillers, opioids, or psychotropic medicines.
Pregnancy & Breastfeeding
Safe use during pregnancy has not been established. Tramadol is known to cross the placenta, and there are no adequate, well-controlled studies in pregnant women. For this reason, it should be used in pregnancy only if the expected benefit to the mother outweighs the potential risk to the unborn baby. Tramadol Hydrochloride should not be used while breastfeeding, since both the drug and its breakdown products pass into breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Tramadol Hydrochloride can be given to children from 1 year of age, at a dose of 1 to 2 mg/kg body weight. The suppository (100 mg Tramadol Hydrochloride) is different, though, and should not be given to children and adolescents below 14 years of age. Tramadol Hydrochloride 100 mg SR Capsules have not been studied in children, so their safety and efficacy have not been established and the product should not be used in children.
Storage
Store Tramadol Hydrochloride below 30°C, and keep it away from light and moisture. Always keep it out of the reach of children.
Drug Interactions
Common questions about Doloran 100 mg
What is Doloran 100 mg Suppository?
Doloran 100 mg Suppository is a medicine that contains Tramadol Hydrochloride. It is made by Nevian Lifescience PLC. It belongs to the Opioid analgesics group of medicines.
What is Doloran used for?
Doloran is used for: Pain, Osteoporosis, Low Back Pain, Cancer.
What are the side effects of Doloran?
Common side effects include dizziness, a spinning sensation (vertigo), nausea, constipation, headache, drowsiness, vomiting, itching, CNS stimulation, weakness, sweating, indigestion, dry mouth, and diarrhoea. Less commonly, it may cause malaise, allergic reaction, weight loss, vasodilatation, palpitations, abdominal pain, loss of appetite, flatulence, gastrointestinal bleeding, hepatitis, and mouth inflammation (stomatitis), among others.
Can I take Doloran during pregnancy or while breastfeeding?
Safe use during pregnancy has not been established. Tramadol is known to cross the placenta, and there are no adequate, well-controlled studies in pregnant women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Doloran?
Store Tramadol Hydrochloride below 30°C, and keep it away from light and moisture. Always keep it out of the reach of children.
Can I take other medicines with Doloran?
Some medicines can interact with Tramadol Hydrochloride, for example: Vortioxetine Hydrobromide, Carbamazepine, Mefloquine, Mirtazapine, Amisulpride, Bupropion Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Kingdol by Drug International Unani Ltd. has the same ingredient and strength for ৳15.00 per unit, compared with ৳20.00 for Doloran. Ask your doctor or pharmacist before switching.
Do I need a prescription for Doloran?
Doloran is a prescription (Rx) medicine. Take it as your doctor advises.