Indications
Pharmacology
Tolfenamic acid (N-(2-methyl-3-chlorophenyl) anthranilic acid) belongs to the fenamate group. It is a strong inhibitor of the cyclooxygenase enzyme, so it blocks the making of important inflammatory mediators such as thromboxane (TX) B2 and prostaglandin (PG) E2. Prostaglandins are what cause swelling, pain and inflammation in these conditions. The medicine works in two ways. Besides stopping prostaglandin synthesis, it also acts directly against prostaglandin receptors.
Pharmacokinetic properties
Absorption: Tolfenamic acid is readily absorbed from the GI tract. Peak plasma concentration is reached in 60 to 90 min. Bioavailability is 85%.
Distribution: About 99% of the drug binds to plasma protein. Plasma half-life is 2 hours.
Metabolism: The medicine is metabolised in the liver. Tolfenamic acid undergoes enterohepatic circulation.
Excretion: Most of it leaves the body in the urine (90%), and the rest is excreted in faeces.
Pregnancy & Breastfeeding
This medicine is not usually recommended during pregnancy unless a doctor considers it essential, and it must not be given during the third trimester. NSAIDs can pass into breast milk in very small amounts, so they should be avoided during breastfeeding if possible.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.